Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2042585 | Cell Reports | 2012 | 7 Pages |
Abstract
⺠Monoacylglycerol lipase (MAGL) is a major contributor to brain arachidonic acid pools ⺠MAGL mutation decreases neuroinflammation and amyloid β in Alzheimer's disease mouse ⺠MAGL blockade recapitulates brain prostaglandin and cytokine-lowering effects ⺠MAGL inhibitors may be a next-generation strategy for combating Alzheimer's disease
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Authors
Justin R. Piro, Daniel I. Benjamin, James M. Duerr, YeQing Pi, Cathleen Gonzales, Kathleen M. Wood, Joel W. Schwartz, Daniel K. Nomura, Tarek A. Samad,