Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2396907 | Journal of Exotic Pet Medicine | 2015 | 6 Pages |
The objective of this investigation was to compare the pharmacokinetics of metoclopramide (MET) after intraarterial (IA), intramuscular (IM), subcutaneous (SC), and perrectal (PR) administrations to normal rabbits. In this study, 6 normal New Zealand white rabbits were used in a random crossover design (4 × 4 Latin square) with a 1-week washout period between trials. Each rabbit had been administered MET at a dose of 2 mg/kg IA, IM, and SC, and 4 mg/kg PR. The plasma concentrations of MET were determined by high-performance liquid chromatography. The mean plasma profiles of MET after IA, IM, and SC administrations were similar. The bioavailability of MET when administered IM and SC was 96% and 112%, respectively. The plasma concentrations within the PR group were quite variable, resulting in an extremely low and variable bioavailability with an average of 12%. IM and SC administrations of MET may be useful in treating gastrointestinal disorders in rabbits when arterial or venous access is not available, but PR administration is likely to be unreliable.