Immuno-histochemical determination of humoral immune markers within bacterial induced granuloma formation in Atlantic cod (Gadus morhua L.)

In this study the involvement of several humoral immune parameters of Atlantic cod (Gadus morhua L.) were studied in granuloma formed as a result of infection by Aeromonas salmonicida ssp. achomogenes. The results showed a clear association of immune parameters within the granuloma, in particular the localization of complement component C3, and including evidence for the presence of IgM, APoLP-A1 (Apolipoprotein), CRP-PI and CRP-PII (pentraxin).

► This is an immuno-histochemical study of Atlantic cod (Gadus morhua L.) granuloma. ► Granuloma was induced by Aeromonas salmonicida ssp. achomogenes (Asa). ► Specific antibodies to Asa and cod IgM, C3, ApoLP A1 and pentraxins were used. ► Clear association of immune parameters with the granuloma formation was observed.