Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2432979 | Fish & Shellfish Immunology | 2009 | 6 Pages |
Abstract
A gene encoding a receptor for activated protein kinase C1 homolog has been isolated from the shrimp, Penaeus monodon (Pm-RACK1). The full length Pm-RACK1 cDNA has 957 bp, and an open reading frame encoding a protein of 318 amino acid residues. The protein contains seven WD40 repeats and shares approximately 78% identity with vertebrate RACK1. In adult shrimp, Pm-RACK1 transcripts were detected in all tissues. During WSSV infection, Pm-RACK1 was upregulated in hepatopancreas, stomach and hemocytes. We identified Pm-RACK1 as a specific cellular target protein for VP9, a nonstructural protein of WSSV. The interaction of these two proteins may be involved in mediating intracellular VP9 functions.
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Authors
Moltira Tonganunt, Netnapa Saelee, Wilaiwan Chotigeat, Amornrat Phongdara,