Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2433060 | Fish & Shellfish Immunology | 2009 | 10 Pages |
Abstract
Pentraxins are important molecules in innate defence and play a role in the acute phase response of both mammals and fish. Isolation of cod pentraxins by affinity chromatography using phosphorylcholine agarose revealed two pentraxin-like proteins, referred to as PI and PII proteins. These varied in their overall charge, pentameric and subunit molecular size, glycosylation and N-terminal amino acid sequences. The PI protein was homologous with the CRP-like pentraxin previously described in cod whereas the PII protein was a new CRP homologue, which was characterized by substantial individual heterogeneity with regard to subunit size and relative density. The results indicate considerable genetic variations in the cod pentraxins.
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Authors
Berglind Gisladottir, Sigridur Gudmundsdottir, Linton Brown, Zophonias O. Jonsson, Bergljot Magnadottir,