Facile synthesis of CF3-substituted dienamides via one-pot tandem reactions

A tandem one-pot protocol involving phosphine-promoted annulation reactions of aryl trifluoromethyl ketones and MBH (Morita-Baylis Hillman) carbonates, followed by DBU-mediated aminolysis with secondary alkylamines, was developed. This protocol enables a mild and cost-effective access to a range of trifluoromethylated dienamides from simple starting materials with acceptable yields.