| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5142753 | Chinese Chemical Letters | 2017 | 4 Pages |
Abstract
A series of benzoxepin-5-ones were designed and synthesized by the cyclization of chalcones which were previously found as FXR antagonists. The most potent target compound 10l reduced the plasma and hepatic triglyceride and plasma ALT levels significantly in mice.
Related Topics
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Authors
Guo-Ning Zhang, Yi Huan, Xing Wang, Su-Juan Sun, Zhu-Fang Shen, Wei-Shuo Fang,