| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5142790 | Chinese Chemical Letters | 2017 | 5 Pages |
Abstract
The microbial transformation of glycyrrhetinic acid (1) by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites (2-6). Compounds 2, 5, and 6 showed significant neural anti-inscommatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC50 values of 0.76, 0.94, and 0.16 μmol/L, respectively.
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Authors
Yuan Ma, Ji-Mei Liu, Ri-Dao Chen, Xi-Qiang An, Jun-Gui Dai,