| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5143005 | Chinese Chemical Letters | 2017 | 6 Pages |
Abstract
Two series of new double pyrazole Schiff base derivatives 4a-4t and 5a-5p as anti-TMV agents were designed and synthesized, in which compound 4j showed the most potent anti-TMV activity. Molecular docking revealed 5-chloro-3-methyl-1H-pyrazole as scaffold of compound 4j could insert into the nucleotide sequence (GAAGUU) of Ori-RNA target pocket stably.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Xian-Hai Lv, Zi-Li Ren, Dong-Dong Li, Ban-Feng Ruan, Qing-Shan Li, Ming-Jie Chu, Cheng-Ying Ai, Dao-Hong Liu, Kai Mo, Hai-Qun Cao,