| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5143013 | Chinese Chemical Letters | 2017 | 4 Pages |
Abstract
The optimization and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities.
Keywords
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Physical Sciences and Engineering
Chemistry
Chemistry (General)
![Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors](/preview/png/5143013.png "First Page Preview: Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors")
Authors
Wei-Huang Zhou, Xi-Guo Xu, Jin Li, Xiao Min, Jian-Zhong Yao, Guo-Qiang Dong, Chun-Lin Zhuang, Zhen-Yuan Miao, Wan-Nian Zhang,