| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5143023 | Chinese Chemical Letters | 2017 | 5 Pages |
Abstract
Valuable chiral N-Boc-β-benzyl-β-amino acid was concisely synthesized via construction of chiral N-Boc-3-benzyl-5-oxoisoxazolidine through cross-metathesis/conjugate addition/oxidation. All of the starting materials for the synthesis of chiral β-benzyl-β-amino acid are cheap, and two-step short procedure make it easy for the rapid construction of various chiral β-arylmethyl-β-amino acids and important drugs, such as sitagliptin phosphate.
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Authors
Hong-Tao Jiang, Hao-Ling Gao, Cheng-Sheng Ge,