Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5143117 | Chinese Chemical Letters | 2017 | 4 Pages |
Abstract
C8-Alkyl-substituted purine analogues were synthesized through direct alkylation of 8-H purine with tetrahydrofuran in the presence of Co catalyst in one step. The reactions gave a series of novel C8-oxygen heterocyclic alkyl purine compounds in good yields under mild reaction conditions by the readily available alkylating reagents, providing a complementary route to the classical coupling reactions for the synthesis of C8-alkyl-substituted purine analogues.71
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Authors
Hong-Ying Niu, Ling-Yun Su, Shi-Xia Bai, Jian-Ping Li, Xi-Lan Feng, Hai-Ming Guo,