Advances in engineering methylotrophic yeast for biosynthesis of valuable chemicals from methanol

Methylotrophic yeasts, which can use methanol as carbon and energy source, have been wildly used as microbial cell factories for biomanufacturing. Methanol derived from diverse sources could be transformed into precursor, such as pyruvate and acetyl-CoA, for the production of valuable chemicals through genetic engineering of methylotrophic yeast.