| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7693249 | Chinese Chemical Letters | 2018 | 8 Pages |
Abstract
Based on a mechanism analogous to the serine/threonine ligation, the aspartic acid ligation, which is facilitated by the γ-amino alcohol based ligation and oxidation, is developed and applied to the synthesis of cyclic peptides. The γ-hydroxyl group triggers the ring-chain tautomerization via a 6-endo-trig process, while the δ-hydroxyl group facilitates the oxidative cleavage of the vicinal diol to give carboxylic acid.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Ci Xu, Jianchao Xu, Han Liu, Xuechen Li,