Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8498051 | Fish & Shellfish Immunology | 2018 | 7 Pages |
Abstract
For the aim to study potential detrimental effects induced by Cu exposure at low, environmentally relevant concentrations, the in vivo activities at different levels of biological organisations of thick shell mussel Mytilus coruscus exposed to two levels of copper were assessed. Cu-induced stresses were evaluated through antioxidant responses, DNA damage and genotoxicity. The results revealed significant higher SOD and CAT activities, and MDA concentration in haemocytes of M. coruscus with Cu exposure at 8â¯Î¼g/L, while only significant accumulation in CAT activity with Cu exposure at 2â¯Î¼g/L and no significant changes with SOD activity and MDA concentration at this level of Cu exposure. Copper exposure induced DNA damage as induction of OTM value in a time- and concentration-dependent manner. In addition, copper exposure could significantly induced the expressions of MT-10, Hsp70, Hsp90 and C3. The present results deepen the mussels as a suitable model marine invertebrate species to study potential detrimental effects induced by possible toxicants, in combinations at different levels of biological organisations.
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Authors
Kaida Xu, Zurong Tang, Shuobo Liu, Zhi liao, Hu Xia, Lianwei Liu, Zhongming Wang, Pengzhi Qi,