Alanine Scanning of MS2 Coat Protein Reveals Protein–Phosphate Contacts Involved in Thermodynamic Hot Spots Fulltext Access 12 Pages 2006
GTP-dependent Formation of a Ribonucleoprotein Subcomplex Required for Ribosome Biogenesis Fulltext Access 12 Pages 2006
Cis and Trans-acting Effects on a Mutational Hotspot Involving a Replication Template Switch Fulltext Access 12 Pages 2006
Recognition of Oxidatively Modified Bases within the Biotin-binding Site of Avidin Fulltext Access 12 Pages 2006
The 1.6 Å X-ray Structure of the Unusual c-type Cytochrome, Cytochrome cL, from the Methylotrophic Bacterium Methylobacterium extorquens Fulltext Access 12 Pages 2006
Characterization of Dual Substrate Binding Sites in the Homodimeric Structure of Escherichia coli mRNA Interferase MazF Fulltext Access 12 Pages 2006
Early Effects of Topoisomerase I Inhibition on RNA Polymerase II Along Transcribed Genes in Human Cells Fulltext Access 12 Pages 2006
Model for RNA Binding and the Catalytic Site of the RNase Kid of the Bacterial parD Toxin–Antitoxin System Fulltext Access 12 Pages 2006
R-state Haemoglobin with Low Oxygen Affinity: Crystal Structures of Deoxy Human and Carbonmonoxy Horse Haemoglobin Bound to the Effector Molecule L35 Fulltext Access 12 Pages 2006
Polymorphism of Bulged-out Residues in HIV-1 RNA DIS Kissing Complex and Structure Comparison with Solution Studies Fulltext Access 12 Pages 2006
Amyloid-β Peptide Disruption of Lipid Membranes and the Effect of Metal Ions Fulltext Access 12 Pages 2006
Time-resolved Small-angle X-ray Scattering Investigation of the Folding Dynamics of Heme Oxygenase: Implication of the Scaling Relationship for the Submillisecond Intermediates of Protein Folding Fulltext Access 12 Pages 2006
Crystal Structures of Human Glycerol 3-phosphate Dehydrogenase 1 (GPD1) Fulltext Access 12 Pages 2006
A Novel-type Substrate-selectivity Filter and ER-exit Determinants in the UapA Purine Transporter Fulltext Access 12 Pages 2006
A Pathway for the Transmission of Allosteric Signals in the Ribosome through a Network of RNA Tertiary Interactions Fulltext Access 12 Pages 2006
Protein Translocation through the Anthrax Toxin Transmembrane Pore is Driven by a Proton Gradient Fulltext Access 12 Pages 2006
Visualization of the Annealing of Complementary Single-stranded DNA Catalyzed by the Herpes Simplex Virus Type 1 ICP8 SSB/Recombinase Fulltext Access 12 Pages 2006
Efficient Prediction of Nucleic Acid Binding Function from Low-resolution Protein Structures Fulltext Access 12 Pages 2006
Reconstitution of Calmodulin from Domains and Subdomains: Influence of Target Peptide Fulltext Access 12 Pages 2006
The Crystal Structure of the Apoenzyme of the Iron–Sulphur Cluster-free Hydrogenase Fulltext Access 12 Pages 2006
Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen Fulltext Access 12 Pages 2006
Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man Fulltext Access 12 Pages 2006
Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes Fulltext Access 12 Pages 2006
Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel Fulltext Access 12 Pages 2006
Prolonged oxidative stress inverts the cardiac force–frequency relation: role of altered calcium handling and myofilament calcium responsiveness Fulltext Access 12 Pages 2006
Ischemia/reperfusion-induced death of cardiac myocytes: possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia Fulltext Access 12 Pages 2006
Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling Fulltext Access 12 Pages 2006
Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation Fulltext Access 12 Pages 2006
Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy Fulltext Access 12 Pages 2006
Norepinephrine-induced changes in gene expression of phospholipase C in cardiomyocytes Fulltext Access 12 Pages 2006
Attenuation of cardiac dysfunction by a PPAR-α agonist is associated with down-regulation of redox-regulated transcription factors Fulltext Access 12 Pages 2006
Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats Fulltext Access 12 Pages 2006
Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes Fulltext Access 12 Pages 2006
Compensated volume overload increases the vulnerability of heart mitochondria without affecting their functions in the absence of stress Fulltext Access 12 Pages 2006
Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats Fulltext Access 12 Pages 2006
Cryo-electron Microscopy Reveals Conserved and Divergent Features of Gag Packing in Immature Particles of Rous Sarcoma Virus and Human Immunodeficiency Virus Fulltext Access 12 Pages 2006
Kinetic Studies of Folding of the B-domain of Staphylococcal Protein A with Molecular Dynamics and a United-residue (UNRES) Model of Polypeptide Chains Fulltext Access 12 Pages 2006
Characterization of the DNA Binding Features of Saccharomyces castellii Cdc13p Fulltext Access 12 Pages 2006
Effect of Hsp70 Chaperone on the Folding and Misfolding of Polypeptides Modeling an Elongating Protein Chain Fulltext Access 12 Pages 2006
d-3-Hydroxybutyrate Dehydrogenase from Pseudomonas fragi: Molecular Cloning of the Enzyme Gene and Crystal Structure of the Enzyme Fulltext Access 12 Pages 2006
Implications of the Aquaporin-4 Structure on Array Formation and Cell Adhesion Fulltext Access 12 Pages 2006
Capsaicin induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE 81T/VGH cells through the elevation of intracellular reactive oxygen species and Ca2+ productions and caspase-3 activation Fulltext Access 12 Pages 2006
Bystander-mediated genomic instability after high LET radiation in murine primary haemopoietic stem cells Fulltext Access 12 Pages 2006
Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver Fulltext Access 12 Pages 2006
Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures Fulltext Access 12 Pages 2006
Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid Fulltext Access 12 Pages 2006
Indirect mechanisms of genomic instability and the biological significance of mutations at tandem repeat loci Fulltext Access 12 Pages 2006
Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) Fulltext Access 12 Pages 2006
Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae Fulltext Access 12 Pages 2006
Efficient repair of bleomycin-induced double-strand breaks in barley ribosomal genes Fulltext Access 12 Pages 2006
Can individual repair kinetics of UVC-induced DNA damage in human lymphocytes be assessed through the comet assay? Fulltext Access 12 Pages 2006
Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair Fulltext Access 12 Pages 2006
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks Fulltext Access 12 Pages 2006
Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair Fulltext Access 12 Pages 2006
Comparative investigations of sodium arsenite, arsenic trioxide and cadmium sulphate in combination with gamma-radiation on apoptosis, micronuclei induction and DNA damage in a human lymphoblastoid cell line Fulltext Access 12 Pages 2006
Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Fulltext Access 12 Pages 2006
Non-random distribution of instability-associated chromosomal rearrangement breakpoints in human lymphoblastoid cells Fulltext Access 12 Pages 2006
Environmental and nutritional effects on the epigenetic regulation of genes Fulltext Access 12 Pages 2006
Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies Fulltext Access 12 Pages 2006
Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay Fulltext Access 12 Pages 2006
Tandem Sp1/Sp3 sites together with an Ets-1 site cooperate to mediate α11 integrin chain expression in mesenchymal cells Fulltext Access 12 Pages 2006
Differential cell adhesion to vocal fold extracellular matrix constituents Fulltext Access 12 Pages 2006
Both direct and collagen-mediated signals are required for active vitamin D3-elicited differentiation of human osteoblastic cells: Roles of osterix, an osteoblast-related transcription factor Fulltext Access 12 Pages 2006
Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13 Fulltext Access 12 Pages 2006
The N-terminal 70-kDa fragment of fibronectin binds to cell surface fibronectin assembly sites in the absence of intact fibronectin Fulltext Access 12 Pages 2006
Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide Fulltext Access 12 Pages 2006
Filling Small, Empty Protein Cavities: Structural and Energetic Consequences Fulltext Access 12 Pages 2006
Bacillus subtilis Bacteriophage SPP1 G40P Helicase Lacking the N-terminal Domain Unwinds DNA Bidirectionally Fulltext Access 12 Pages 2006
High-resolution Crystal Structure of Aldose Reductase Complexed with the Novel Sulfonyl-pyridazinone Inhibitor Exhibiting an Alternative Active Site Anchoring Group Fulltext Access 12 Pages 2006
The Crystal Structure of Polyhydroxybutyrate Depolymerase from Penicillium funiculosum Provides Insights into the Recognition and Degradation of Biopolyesters Fulltext Access 12 Pages 2006
The N-terminal Half of the Peroxisomal Cycling Receptor Pex5p is a Natively Unfolded Domain Fulltext Access 12 Pages 2006
Crystal Structure of a Novel Viral Protease with a Serine/Lysine Catalytic Dyad Mechanism Fulltext Access 12 Pages 2006
Crystal Structure of Isoflavone Reductase from Alfalfa (Medicago sativa L.) Fulltext Access 12 Pages 2006
Artemis Phosphorylated by DNA-dependent Protein Kinase Associates Preferentially with Discrete Regions of Chromatin Fulltext Access 12 Pages 2006
Nanopore–Protein Interactions Dramatically Alter Stability and Yield of the Native State in Restricted Spaces Fulltext Access 12 Pages 2006
Structure of the α-Actinin–Vinculin Head Domain Complex Determined by Cryo-electron Microscopy Fulltext Access 12 Pages 2006
Human endogenous retrovirus HERV-H family in human tissues and cancer cells: expression, identification, and phylogeny Fulltext Access 12 Pages 2006
Structural Basis of the Nucleotide Driven Conformational Changes in the AAA+ Domain of Transcription Activator PspF Fulltext Access 12 Pages 2006
Concordant Exploration of the Kinetics of RNA Folding from Global and Local Perspectives Fulltext Access 12 Pages 2006
Structure of the Escherichia coli Quorum Sensing Protein SdiA: Activation of the Folding Switch by Acyl Homoserine Lactones Fulltext Access 12 Pages 2006
Entropically Driven MHC Class I Recognition by Human Inhibitory Receptor Leukocyte Ig-like Receptor B1 (LILRB1/ILT2/CD85j) Fulltext Access 12 Pages 2006
Local Kinetic Measures of Macromolecular Structure Reveal Partitioning among Multiple Parallel Pathways from the Earliest Steps in the Folding of a Large RNA Molecule Fulltext Access 12 Pages 2006
The Type III Flagellar Export Specificity Switch is Dependent on FliK Ruler and a Molecular Clock Fulltext Access 12 Pages 2006