Structure-Based Prediction of the Peptide Sequence Space Recognized by Natural and Synthetic PDZ Domains Fulltext Access 15 Pages 2010
Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1 Fulltext Access 15 Pages 2010
Size-Independent and Noncooperative Recognition of dsRNA by the Rice Stripe Virus RNA Silencing Suppressor NS3 Fulltext Access 15 Pages 2010
Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality Fulltext Access 15 Pages 2010
M. tuberculosis Pantothenate Kinase: Dual Substrate Specificity and Unusual Changes in Ligand Locations Fulltext Access 15 Pages 2010
Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases Fulltext Access 15 Pages 2010
Effects of Turn Stability and Side-Chain Hydrophobicity on the Folding of β-Structures Fulltext Access 15 Pages 2010
HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics Fulltext Access 15 Pages 2010
Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate Fulltext Access 15 Pages 2010
Structure and Function of P19, a High-Affinity Iron Transporter of the Human Pathogen Campylobacter jejuni Fulltext Access 15 Pages 2010
Molecular Basis for the Structural Stability of an Enclosed β-Barrel Loop Fulltext Access 15 Pages 2010
Insights into Strand Exchange in BTB Domain Dimers from the Crystal Structures of FAZF and Miz1 Fulltext Access 15 Pages 2010
The Single-Stranded DNA Binding Protein of Sulfolobus solfataricus Acts in the Presynaptic Step of Homologous Recombination Fulltext Access 15 Pages 2010
Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids Fulltext Access 15 Pages 2010
Alternative Oligomeric States of the Yeast Rvb1/Rvb2 Complex Induced by Histidine Tags Fulltext Access 15 Pages 2010
Reversible Adenylylation of Glutamine Synthetase Is Dynamically Counterbalanced during Steady-State Growth of Escherichia coli Fulltext Access 15 Pages 2010
Structural Similarity between the Prion Domain of HET-s and a Homologue Can Explain Amyloid Cross-Seeding in Spite of Limited Sequence Identity Fulltext Access 15 Pages 2010
Molecular Architecture of the Mn2+-dependent Lactonase UlaG Reveals an RNase-like Metallo-β-lactamase Fold and a Novel Quaternary Structure Fulltext Access 15 Pages 2010
Discoidin I from Dictyostelium discoideum and Interactions with Oligosaccharides: Specificity, Affinity, Crystal Structures, and Comparison with Discoidin II Fulltext Access 15 Pages 2010
The Mechanism of HIV-1 Tat-Directed Nucleic Acid Annealing Supports its Role in Reverse Transcription Fulltext Access 15 Pages 2010
Interactions Between Late-Acting Proteins Required for Peptidoglycan Synthesis during Sporulation Fulltext Access 15 Pages 2010
Structure of the Cytosolic Portion of the Motor Protein Prestin and Functional Role of the STAS Domain in SLC26/SulP Anion Transporters Fulltext Access 15 Pages 2010
Comparative Analysis of Membrane-Associated Fusion Peptide Secondary Structure and Lipid Mixing Function of HIV gp41 Constructs that Model the Early Pre-Hairpin Intermediate and Final Hairpin Conformations Fulltext Access 15 Pages 2010
Molecular Mechanism of Polypeptide Translocation Catalyzed by the Escherichia coli ClpA Protein Translocase Fulltext Access 15 Pages 2010
Protein Roles in Group I Intron RNA Folding: The Tyrosyl-tRNA Synthetase CYT-18 Stabilizes the Native State Relative to a Long-Lived Misfolded Structure without Compromising Folding Kinetics Fulltext Access 15 Pages 2010
The Crystal Structure of Bacteriophage HK97 gp6: Defining a Large Family of Head–Tail Connector Proteins Fulltext Access 15 Pages 2010
A Transmembrane Polar Interaction Is Involved in the Functional Regulation of Integrin αLβ2 Fulltext Access 15 Pages 2010
Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases Fulltext Access 15 Pages 2010
Enhanced Specificity of Mint Geranyl Pyrophosphate Synthase by Modifying the R-Loop Interactions Fulltext Access 15 Pages 2010
HBx-Induced Hepatic Steatosis and Apoptosis Are Regulated by TNFR1- and NF-κB-Dependent Pathways Fulltext Access 15 Pages 2010
Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces Fulltext Access 15 Pages 2010
Quantitative Proteomic Analysis of Ribosome Assembly and Turnover In Vivo Fulltext Access 15 Pages 2010
Ab initio Hartree–Fock and density functional theory investigations on the conformational stability, molecular structure and vibrational spectra of 3-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)benzo[d]thiazol-2(3H)-one Fulltext Access 15 Pages 2010
Computational Design of a Chain-Specific Tetracycline Repressor Heterodimer Fulltext Access 15 Pages 2010
Glucagon Fibril Polymorphism Reflects Differences in Protofilament Backbone Structure Fulltext Access 15 Pages 2010
The 2.2-Å Structure of the HP0958 Protein from Helicobacter pylori Reveals a Kinked Anti-Parallel Coiled-Coil Hairpin Domain and a Highly Conserved Zn-Ribbon Domain Fulltext Access 15 Pages 2010
Structure, Evolutionary Conservation, and Conformational Dynamics of Homo sapiens Fascin-1, an F-actin Crosslinking Protein Fulltext Access 16 Pages 2010
High-Resolution Crystal Structures of Drosophila melanogaster Angiotensin-Converting Enzyme in Complex with Novel Inhibitors and Antihypertensive Drugs Fulltext Access 16 Pages 2010
Key Amino Acid Residues Involved in Multi-Point Binding Interactions between Brazzein, a Sweet Protein, and the T1R2–T1R3 Human Sweet Receptor Fulltext Access 16 Pages 2010
Insights into the composition, morphology, and formation of the calcareous shell of the serpulid Hydroides dianthus Fulltext Access 16 Pages 2010
Structure of the RNA Binding Domain of a DEAD-Box Helicase Bound to Its Ribosomal RNA Target Reveals a Novel Mode of Recognition by an RNA Recognition Motif Fulltext Access 16 Pages 2010
Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput Fulltext Access 16 Pages 2010
Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of α-Synuclein Aggregation Fulltext Access 16 Pages 2010
Structure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated Glycan Fulltext Access 16 Pages 2010
Mechanism of U Insertion RNA Editing in Trypanosome Mitochondria: The Bimodal TUTase Activity of the Core Complex Fulltext Access 16 Pages 2010
Structural Analysis of Cysteine S-Nitrosylation: A Modified Acid-Based Motif and the Emerging Role of Trans-Nitrosylation Fulltext Access 16 Pages 2010
Activation of the Ghrelin Receptor is Described by a Privileged Collective Motion: A Model for Constitutive and Agonist-induced Activation of a Sub-class A G-Protein Coupled Receptor (GPCR) Fulltext Access 16 Pages 2010
Structural Tightening and Interdomain Communication in the Catalytic Cycle of Phosphoglycerate Kinase Fulltext Access 16 Pages 2010
The 19S ATPase S6a (S6′/TBP1) Regulates the Transcription Initiation of Class II Transactivator Fulltext Access 16 Pages 2010
Dissection of the IgNAR V Domain: Molecular Scanning and Orthologue Database Mining Define Novel IgNAR Hallmarks and Affinity Maturation Mechanisms Fulltext Access 16 Pages 2010
Molecular Mechanisms of Rhodopsin Retinitis Pigmentosa and the Efficacy of Pharmacological Rescue Fulltext Access 16 Pages 2010
Mechanism of Fiber Assembly: Treatment of Aβ Peptide Aggregation with a Coarse-Grained United-Residue Force Field Fulltext Access 16 Pages 2010
Triosephosphate Isomerase: 15N and 13C Chemical Shift Assignments and Conformational Change upon Ligand Binding by Magic-Angle Spinning Solid-State NMR Spectroscopy Fulltext Access 16 Pages 2010
Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin–Aspartate Bond Fulltext Access 16 Pages 2010
NMR Solution Structure and DNA-binding Model of the DNA-binding Domain of Competence Protein A Fulltext Access 16 Pages 2010
Reactions of an Aromatic σ,σ-Biradical with Amino Acids and Dipeptides in the Gas Phase Fulltext Access 16 Pages 2010
A spectroscopic and computational study of an electrocyclized photo-degradation product of 6-(2-(5-chloro-2-(2,4-difluorobenyzloxy)phenyl)cyclopent-1-enyl)picolinic acid Fulltext Access 16 Pages 2010
A fully automatic three-step liver segmentation method on LDA-based probability maps for multiple contrast MR images Fulltext Access 16 Pages 2010
Synthesis methods of multiple phase-cycled SSFP images to reduce the band artifact and noise more reliably Fulltext Access 16 Pages 2010
Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer Fulltext Access 16 Pages 2010
SusG: A Unique Cell-Membrane-Associated α-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules Fulltext Access 16 Pages 2010
Cellular Architecture of Treponema pallidum: Novel Flagellum, Periplasmic Cone, and Cell Envelope as Revealed by Cryo Electron Tomography Fulltext Access 16 Pages 2010
Enhancing the Stability and Solubility of the Glucocorticoid Receptor Ligand-Binding Domain by High-Throughput Library Screening Fulltext Access 16 Pages 2010
Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP Fulltext Access 16 Pages 2010
Reversal of a Mutator Activity by a Nearby Fidelity-Neutral Substitution in the RB69 DNA Polymerase Binding Pocket Fulltext Access 16 Pages 2010
SAM Recognition and Conformational Switching Mechanism in the Bacillus subtilis yitJ S Box/SAM-I Riboswitch Fulltext Access 16 Pages 2010
Crystal Structures of NodS N-Methyltransferase from Bradyrhizobium japonicum in Ligand-Free Form and as SAH Complex Fulltext Access 16 Pages 2010
Evidence for Initial Non-specific Polypeptide Chain Collapse During the Refolding of the SH3 Domain of PI3 Kinase Fulltext Access 16 Pages 2010
Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway Fulltext Access 16 Pages 2010
Crystal Structures of Inhibitor Complexes of Human T-Cell Leukemia Virus (HTLV-1) Protease Fulltext Access 16 Pages 2010
TolA Modulates the Oligomeric Status of YbgF in the Bacterial Periplasm Fulltext Access 16 Pages 2010
In silico analysis of cis-acting regulatory elements in 5′ regulatory regions of sucrose transporter gene families in rice (Oryza sativa Japonica) and Arabidopsis thaliana Fulltext Access 16 Pages 2010
Probing the Periplasmic-Open State of Lactose Permease in Response to Sugar Binding and Proton Translocation Fulltext Access 16 Pages 2010
Direct Determination of Protonation States of Histidine Residues in a 2 Å Neutron Structure of Deoxy-Human Normal Adult Hemoglobin and Implications for the Bohr Effect Fulltext Access 16 Pages 2010
Crystal Structure of the Dog Lipocalin Allergen Can f 2: Implications for Cross-reactivity to the Cat Allergen Fel d 4 Fulltext Access 16 Pages 2010
Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization Fulltext Access 16 Pages 2010
The PAX3 Paired Domain and Homeodomain Function as a Single Binding Module In Vivo to Regulate Subnuclear Localization and Mobility by a Mechanism That Requires Base-Specific Recognition Fulltext Access 16 Pages 2010
The Role of Protein Sequence and Amino Acid Composition in Amyloid Formation: Scrambling and Backward Reading of IAPP Amyloid Fibrils Fulltext Access 16 Pages 2010
Induced-fit upon Ligand Binding Revealed by Crystal Structures of the Hot-dog Fold Thioesterase in Dynemicin Biosynthesis Fulltext Access 16 Pages 2010
Collagen XVI induces formation of focal contacts on intestinal myofibroblasts isolated from the normal and inflamed intestinal tract Fulltext Access 17 Pages 2010
Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts Fulltext Access 17 Pages 2010
Macromolecular structure of the organic framework of nacre in Haliotis rufescens: Implications for mechanical response Fulltext Access 17 Pages 2010
Mobile Protons Versus Mobile Radicals: Gas-Phase Unimolecular Chemistry of Radical Cations of Cysteine-Containing Peptides⁎† Fulltext Access 17 Pages 2010
Crystal structure and statistical coupling analysis of highly glycosylated peroxidase from royal palm tree (Roystonea regia) Fulltext Access 17 Pages 2010
Backbone and Side-Chain Specific Dissociations of z Ions from Non-Tryptic Peptides Fulltext Access 17 Pages 2010
Pathogenic Mutations in the Hydrophobic Core of the Human Prion Protein Can Promote Structural Instability and Misfolding Fulltext Access 17 Pages 2010
Actin Filament Bundling and Different Nucleating Effects of Mouse Diaphanous-Related Formin FH2 Domains on Actin/ADF and Actin/Cofilin Complexes Fulltext Access 17 Pages 2010
DHPC Strongly Affects the Structure and Oligomerization Propensity of Alzheimer's Aβ(1–40) Peptide Fulltext Access 17 Pages 2010
H-Bonding and Positive Charge at the N(5)/O(4) Locus Are Critical for Covalent Flavin Attachment in Trametes Pyranose 2-Oxidase Fulltext Access 17 Pages 2010
Dynamic Interactions between Clathrin and Locally Structured Elements in a Disordered Protein Mediate Clathrin Lattice Assembly Fulltext Access 17 Pages 2010
Crystal Structures of the Glutamate Receptor Ion Channel GluK3 and GluK5 Amino-Terminal Domains Fulltext Access 17 Pages 2010