T-RMSD: A Fine-grained, Structure-based Classification Method and its Application to the Functional Characterization of TNF Receptors Fulltext Access 13 Pages 2010
Structural Evidence for the Functional Importance of the Heme Domain Mobility in Flavocytochrome b2 Fulltext Access 13 Pages 2010
The Branched Photocycle of the Slow-Cycling Channelrhodopsin-2 Mutant C128T Fulltext Access 13 Pages 2010
Determinants of Substrate Binding and Protonation in the Flavoenzyme Xenobiotic Reductase A Fulltext Access 13 Pages 2010
Stability and CDR Composition Biases Enrich Binder Functionality Landscapes Fulltext Access 13 Pages 2010
Crystal Structure of the AmpR Effector Binding Domain Provides Insight into the Molecular Regulation of Inducible AmpC β-Lactamase Fulltext Access 13 Pages 2010
Biophysical Characterisation of Fibulin-5 Proteins Associated with Disease Fulltext Access 13 Pages 2010
Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine Fulltext Access 13 Pages 2010
Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage Fulltext Access 13 Pages 2010
Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b Fulltext Access 13 Pages 2010
Global Network Analysis of Lipid-Raft-Related Proteins Reveals Their Centrality in the Network and Their Roles in Multiple Biological Processes Fulltext Access 13 Pages 2010
Influence of the Cytoplasmic Domains of Aquaporin-4 on Water Conduction and Array Formation Fulltext Access 13 Pages 2010
Mechanism of DNA Methylation: The Double Role of DNA as a Substrate and as a Cofactor Fulltext Access 13 Pages 2010
Structural Insights on the New Mechanism of Trehalose Synthesis by Trehalose Synthase TreT from Pyrococcus horikoshii Fulltext Access 13 Pages 2010
Evidence for Amino Acid Roles in the Chemistry of ATP Hydrolysis in Escherichia coli Rho Fulltext Access 13 Pages 2010
Preformed Protein-binding Motifs in 7SK snRNA: Structural and Thermodynamic Comparisons with Retroviral TAR Fulltext Access 13 Pages 2010
Investigation of an Anomalously Accelerating Substitution in the Folding of a Prototypical Two-State Protein Fulltext Access 13 Pages 2010
A Novel Unstructured Scaffold Based on 4EBP1 Enables the Functional Display of a Wide Range of Bioactive Peptides Fulltext Access 13 Pages 2010
The Contribution of a Covalently Bound Cofactor to the Folding and Thermodynamic Stability of an Integral Membrane Protein Fulltext Access 13 Pages 2010
Chemoenzymatic Synthesis, Inhibition Studies, and X-ray Crystallographic Analysis of the Phosphono Analog of UDP-Galp as an Inhibitor and Mechanistic Probe for UDP-Galactopyranose Mutase Fulltext Access 13 Pages 2010
Structure of a SLC26 Anion Transporter STAS Domain in Complex with Acyl Carrier Protein: Implications for E. coli YchM in Fatty Acid Metabolism Fulltext Access 13 Pages 2010
Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase Fulltext Access 13 Pages 2010
Structure of Concatenated HAMP Domains Provides a Mechanism for Signal Transduction Fulltext Access 13 Pages 2010
Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting Fulltext Access 13 Pages 2010
Glycosaminoglycan mimetics trigger IP3-dependent intracellular calcium release in myoblasts Fulltext Access 13 Pages 2010
Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis Fulltext Access 13 Pages 2010
Molecular interactions in the retinal basement membrane system: A proteomic approach Fulltext Access 13 Pages 2010
A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region Fulltext Access 13 Pages 2010
Crystal Structure and Catalytic Mechanism of Leucoanthocyanidin Reductase from Vitis vinifera Fulltext Access 13 Pages 2010
Non-additivity of Functional Group Contributions in Protein–Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry Fulltext Access 13 Pages 2010
Regulation of Aerobic-to-Anaerobic Transitions by the FNR Cycle in Escherichia coli Fulltext Access 13 Pages 2010
Unfinished Stories on Viral Quasispecies and Darwinian Views of Evolution Fulltext Access 13 Pages 2010
Vortex-Induced Formation of Insulin Amyloid Superstructures Probed by Time-Lapse Atomic Force Microscopy and Circular Dichroism Spectroscopy Fulltext Access 13 Pages 2010
Structural Characterization of Novel Pseudomonas aeruginosa Type IV Pilins Fulltext Access 13 Pages 2010
Calcitriol Upregulates Open Chromatin and Elongation Markers at Functional Vitamin D Response Elements in the Distal Part of the 5-Lipoxygenase Gene Fulltext Access 13 Pages 2010
Structural Insights into Substrate Recognition and Product Expulsion in CTX-M Enzymes Fulltext Access 13 Pages 2010
Crystal Structures of an Oligopeptide-Binding Protein from the Biosynthetic Pathway of the β-Lactamase Inhibitor Clavulanic Acid Fulltext Access 13 Pages 2010
A Single Mutation at the Sheet Switch Region Results in Conformational Changes Favoring λ6 Light-Chain Fibrillogenesis Fulltext Access 13 Pages 2010
PAH-Domain-Specific Interactions of the Arabidopsis Transcription Coregulator SIN3-LIKE1 (SNL1) with Telomere-Binding Protein 1 and ALWAYS EARLY2 Myb-DNA Binding Factors Fulltext Access 13 Pages 2010
Viral Genomic Single-Stranded RNA Directs the Pathway Toward a T = 3 Capsid Fulltext Access 13 Pages 2010
Calcium-Induced Folding of a Beta Roll Motif Requires C-Terminal Entropic Stabilization Fulltext Access 13 Pages 2010
Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases Fulltext Access 13 Pages 2010
Oligomeric State in the Crystal Structure of Modular FAD Synthetase Provides Insights into Its Sequential Catalysis in Prokaryotes Fulltext Access 13 Pages 2010
Crystal Structure of the ATPPase Subunit and Its Substrate-Dependent Association with the GATase Subunit: A Novel Regulatory Mechanism for a Two-Subunit-Type GMP Synthetase from Pyrococcus horikoshii OT3 Fulltext Access 13 Pages 2010
The Shape and Flexibility of Tropomyosin Coiled Coils: Implications for Actin Filament Assembly and Regulation Fulltext Access 13 Pages 2010
Cysteine-to-Serine Mutants Dramatically Reorder the Active Site of Human ABO(H) Blood Group B Glycosyltransferase without Affecting Activity: Structural Insights into Cooperative Substrate Binding Fulltext Access 13 Pages 2010
Inhibiting NF-κB activation by small molecules as a therapeutic strategy Fulltext Access 13 Pages 2010
The cspA mRNA Is a Thermosensor that Modulates Translation of the Cold-Shock Protein CspA Fulltext Access 13 Pages 2010
Charge-transfer complexes of sulfamethoxazole drug with different classes of acceptors Fulltext Access 13 Pages 2010
The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor Fulltext Access 13 Pages 2010
Mus81 and Yen1 Promote Reciprocal Exchange during Mitotic Recombination to Maintain Genome Integrity in Budding Yeast Fulltext Access 13 Pages 2010
Transcriptional upregulation of calcineurin Aβ by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIδ3 in rat cardiomyocytes Fulltext Access 13 Pages 2010
Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase Fulltext Access 13 Pages 2010
Binding and interplay of HMG proteins on chromatin: Lessons from live cell imaging Fulltext Access 13 Pages 2010
Adaptive smoothing of high angular resolution diffusion-weighted imaging data by generalized cross-validation improves Q-ball orientation distribution function reconstruction Fulltext Access 13 Pages 2010
Microwave, Raman, and infrared spectra, r0 structural parameters, conformational stability, and vibrational assignment of cyanocyclohexane Fulltext Access 13 Pages 2010
Crystal structures and vibrational spectra of novel compounds with dimeric glycine glycinium cations Fulltext Access 13 Pages 2010
Synthesis of zinc phthalocyanine derivatives with improved photophysicochemical properties in aqueous media Fulltext Access 13 Pages 2010
The structure of N-allyl-(5-phenyl-[1,3,4]thiadiazol-2-yl) amine in solution and the solid state studied by the 1H, 13C, 15N NMR spectroscopy and X-ray crystallography Fulltext Access 13 Pages 2010
Hydrogen and halogen bonding patterns and π–π aromatic interactions of some 6,7-disubstituted 1,3-benzothiazoles studied by X-ray diffraction and DFT calculations Fulltext Access 13 Pages 2010
The molecular structure of 1,1-dichlorosilacyclopentane as obtained from gas-phase electron diffraction and ab initio calculations Fulltext Access 13 Pages 2010
Tripodal molecules derived from ethanoldithiazinanes centered on boron and phosphorus atoms. Structural analyses by NMR and HF/6-31G(d) calculations Fulltext Access 13 Pages 2010
The role of hydrogen atoms in interactions involving imidazolium-based ionic liquids Fulltext Access 13 Pages 2010
Lipid-Induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6 Fulltext Access 13 Pages 2010
Deciphering the Deformation Modes Associated with Function Retention and Specialization in Members of the Ras Superfamily Fulltext Access 13 Pages 2010
Structure of the GLD-1 Homodimerization Domain: Insights into STAR Protein-Mediated Translational Regulation Fulltext Access 13 Pages 2010
Quantitative Structural Analysis of Importin-β Flexibility: Paradigm for Solenoid Protein Structures Fulltext Access 13 Pages 2010
Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader Fulltext Access 13 Pages 2010
SWI/SNF Has Intrinsic Nucleosome Disassembly Activity that Is Dependent on Adjacent Nucleosomes Fulltext Access 13 Pages 2010
Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply Fulltext Access 13 Pages 2010
Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination Fulltext Access 13 Pages 2010
DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis Fulltext Access 13 Pages 2010
CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation Fulltext Access 13 Pages 2010
The Connecdenn DENN Domain: A GEF for Rab35 Mediating Cargo-Specific Exit from Early Endosomes Fulltext Access 13 Pages 2010
A Cell-Type-Specific Protein-Protein Interaction Modulates Transcriptional Activity of a Master Regulator in Caulobacter crescentus Fulltext Access 13 Pages 2010
The Methyltransferase Activity of Clr4Suv39h Triggers RNAi Independently of Histone H3K9 Methylation Fulltext Access 13 Pages 2010
Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex Fulltext Access 13 Pages 2010
Imaging-Based Identification of a Critical Regulator of FtsZ Protofilament Curvature in Caulobacter Fulltext Access 13 Pages 2010
HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II Fulltext Access 13 Pages 2010
AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling Fulltext Access 13 Pages 2010
Tie1-Tie2 Interactions Mediate Functional Differences between Angiopoietin Ligands Fulltext Access 13 Pages 2010
MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells Fulltext Access 13 Pages 2010
Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl Fulltext Access 13 Pages 2010
Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins) Fulltext Access 14 Pages 2010
Single-dose and chronic corticosterone treatment alters c-Fos or FosB immunoreactivity in the rat cerebral cortex Fulltext Access 14 Pages 2010
Effects of asbestiform antigorite on human alveolar epithelial A549 cells: A morphological and immunohistochemical study Fulltext Access 14 Pages 2010
Differential regulation of FGF-2 in neurons and reactive astrocytes of axotomized rat hypoglossal nucleus. A possible therapeutic target for neuroprotection in peripheral nerve pathology Fulltext Access 14 Pages 2010