Quaternary ammonium substituted thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides: Potential membrane-impermeable inhibitors of carbonic anhydrase Fulltext Access 8 Pages 2006
Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: Synthesis and preliminary evaluation as antimicrobial agents Fulltext Access 8 Pages 2006
Synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-thione derivatives as potential calcium channel blockers Fulltext Access 8 Pages 2006
Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase Fulltext Access 8 Pages 2006
An efficient synthesis and biological activity of substituted p-benzoquinones Fulltext Access 8 Pages 2006
Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential Fulltext Access 8 Pages 2006
In vitro aldose reductase inhibitory activity of 5-benzyl-2,4-thiazolidinediones Fulltext Access 8 Pages 2006
Synthesis, cytotoxicity, and DNA-topoisomerase inhibitory activity of new asymmetric ureas and thioureas Fulltext Access 8 Pages 2006
Engineering non-natural inhibitor sensitivity in protein tyrosine phosphatase H1 Fulltext Access 8 Pages 2006
Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on d-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages Fulltext Access 8 Pages 2006
An image contrast agent selectively activated by prostate specific antigen Fulltext Access 8 Pages 2006
Synthesis and evaluation of novel enhanced gene reporter molecules: Detection of β-galactosidase activity using 19F NMR of trifluoromethylated aryl β-d-galactopyranosides Fulltext Access 8 Pages 2006
Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa Fulltext Access 8 Pages 2006
Synthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives as potential antimicrobial agents Fulltext Access 8 Pages 2006
An evaluation of automated in silico ligand docking of amino acid ligands to Family C G-protein coupled receptors Fulltext Access 8 Pages 2006
Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ETA receptor radioligands Fulltext Access 8 Pages 2006
Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent Fulltext Access 8 Pages 2006
Design, synthesis, and biological evaluation of alcyopterosin A and illudalane derivatives as anticancer agents Fulltext Access 8 Pages 2006
Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives Fulltext Access 8 Pages 2006
Lipase-catalyzed preparation of optically active 1′-acetoxychavicol acetates and their structure–activity relationships in apoptotic activity against human leukemia HL-60 cells Fulltext Access 8 Pages 2006
Enantiomeric N-methyl-4-piperidyl benzilates as muscarinic receptor ligands: Radioligand binding studies and docking studies to models of the three muscarinic receptors M1, M2 and M3 Fulltext Access 8 Pages 2006
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities Fulltext Access 8 Pages 2006
Studies of interaction of trichloro{η2-cis-N,N-dimethyl-1-[6-(Nâ²,Nâ²-dimethyl-ammoniummethyl)-cyclohex-3-ene-1-yl]-methylammonium}platinum(II) chloride with DNA: Effects on secondary and tertiary structures of DNA. Cytotoxic assays on human ovarian ca Fulltext Access 8 Pages 2006
Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors Fulltext Access 8 Pages 2006
Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors Fulltext Access 8 Pages 2006
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin β4 in A549 human lung cancer cells Fulltext Access 8 Pages 2006
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers Fulltext Access 8 Pages 2006
Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5-b]- and pyrazolo[3,4-b]quinolines Fulltext Access 8 Pages 2006
Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure–activity relationship of potent inhibitory activity against DNA topoisomerase I Fulltext Access 8 Pages 2006
Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases Fulltext Access 8 Pages 2006
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists Fulltext Access 8 Pages 2006
Synthesis of imidazoline and imidazo[2,1-c][1,2,4]triazole aryl derivatives containing the methylthio group as possible antibacterial agents Fulltext Access 8 Pages 2006
Artepillin C isoprenomics: Design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity Fulltext Access 8 Pages 2006
Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl α-ketoamide derivatives containing pyridine moiety Fulltext Access 8 Pages 2006
Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1 Fulltext Access 8 Pages 2006
One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation Fulltext Access 8 Pages 2006
Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives Fulltext Access 8 Pages 2006
Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives Fulltext Access 8 Pages 2006
Molecular modeling of non-covalent binding of homochiral (3S,3′S)-astaxanthin to matrix metalloproteinase-13 (MMP-13) Fulltext Access 8 Pages 2006
Cysteine based novel noncompetitive inhibitors of urease(s)—Distinctive inhibition susceptibility of microbial and plant ureases Fulltext Access 8 Pages 2006
Synthesis of benzenepropanamine analogues as non-detergent spermicides with antitrichomonas and anticandida activities Fulltext Access 8 Pages 2006
Loss of antagonistic activity of tamoxifen by replacement of one N-methyl of its side chain by fluorinated residues Fulltext Access 8 Pages 2006
Novel A-ring homodimeric C-3-carbamate analogues of 1α,25-dihydroxyvitamin D3: Synthesis and preliminary biological evaluation Fulltext Access 8 Pages 2006
Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety Fulltext Access 8 Pages 2006
Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure–activity relationship Fulltext Access 8 Pages 2006
Synthesis and biological activity of N,N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives Fulltext Access 8 Pages 2006
Synthesis and receptor binding affinity of carboxylate analogues of the mannose 6-phosphate recognition marker Fulltext Access 8 Pages 2006
Design, synthesis, and evaluation of new type of l-amino acids containing pyridine moiety as nitric oxide synthase inhibitor Fulltext Access 8 Pages 2006
Synthesis and biological activity of tricyclic analogues of 9-{[cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine Fulltext Access 8 Pages 2006
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists Fulltext Access 8 Pages 2006
Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation Fulltext Access 8 Pages 2006
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: Design, synthesis, and microbiological evaluation Fulltext Access 8 Pages 2006
The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity Fulltext Access 8 Pages 2006
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa Fulltext Access 8 Pages 2006
Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue Fulltext Access 8 Pages 2006
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors Fulltext Access 8 Pages 2006
Inhibition of protein kinase C by dequalinium analogues: Structure–activity studies on head group variations Fulltext Access 8 Pages 2006
On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors Fulltext Access 8 Pages 2006
Numerical simulation of trace element transport on subsurface environment pollution in coal mine spoil Fulltext Access 8 Pages 2006
Representation in stochastic search for phylogenetic tree reconstruction Fulltext Access 8 Pages 2006
Decision support for acute problems: The role of the standardized patient in usability testing Fulltext Access 8 Pages 2006
Oxygen saturation regularity analysis in the diagnosis of obstructive sleep apnea Fulltext Access 8 Pages 2006
Synthesis and antitumor activity of novel 10-substituted camptothecin analogues Fulltext Access 8 Pages 2006
Classification of dopamine antagonists using functional feature hypothesis and topological descriptors Fulltext Access 8 Pages 2006
New substrates and inhibitors of γ-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: Design, synthesis, and biological activity Fulltext Access 8 Pages 2006
Computer-aided analysis of the interactions of glutamine synthetase with its inhibitors Fulltext Access 8 Pages 2006
Structure–activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata Fulltext Access 8 Pages 2006
Potent antibacterial lysine–peptoid hybrids identified from a positional scanning combinatorial library Fulltext Access 8 Pages 2006
Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues Fulltext Access 8 Pages 2006
Classification of dopamine, serotonin, and dual antagonists by decision trees Fulltext Access 8 Pages 2006
Automated synthesis, characterization, and structural analysis of oligonucleotide C-3′-radical precursors Fulltext Access 8 Pages 2006
Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents Fulltext Access 8 Pages 2006
Ester derivatives of annulated tetrahydroazocines: A new class of selective acetylcholinesterase inhibitors Fulltext Access 8 Pages 2006
Synthesis and QSAR studies of novel triazole compounds containing thioamide as potential antifungal agents Fulltext Access 8 Pages 2006
(±)-3′-O, 4′-O-dicynnamoyl-cis-khellactone, a derivative of (±)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells Fulltext Access 8 Pages 2006
Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin–phenol adducts synthesized Fulltext Access 8 Pages 2006
Structure–activity relationship study of flavone compounds with anti-HIV-1 integrase activity: A density functional theory study Fulltext Access 8 Pages 2006
Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol Fulltext Access 8 Pages 2006
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Fulltext Access 8 Pages 2006
Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes Fulltext Access 8 Pages 2006