The interplay between structure and function in intrinsically unstructured proteins Fulltext Access 9 Pages 2005
A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons Fulltext Access 9 Pages 2005
Evidence of differential pH regulation of the Arabidopsis vacuolar Ca2+/H+ antiporters CAX1 and CAX2 Fulltext Access 9 Pages 2005
Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation Fulltext Access 9 Pages 2005
Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily Fulltext Access 9 Pages 2005
TNF-α enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10/CXCL-10 production Fulltext Access 9 Pages 2005
Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays Fulltext Access 9 Pages 2005
Clp upregulates transcription of engA gene encoding a virulence factor in Xanthomonas campestris by direct binding to the upstream tandem Clp sites Fulltext Access 9 Pages 2005
Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells Fulltext Access 9 Pages 2005
The yeast osmosensitive mutant fps1Δ transformed by the cauliflower BobTIP1;1 aquaporin withstand a hypo-osmotic shock Fulltext Access 9 Pages 2005
Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV Fulltext Access 9 Pages 2005
ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells Fulltext Access 9 Pages 2005
Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super-kdr mutation M918T on the IIS4–S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin Fulltext Access 9 Pages 2005
Immune cell-induced synthesis of NO and reactive oxygen species in lymphoma cells causes their death by apoptosis Fulltext Access 9 Pages 2005
High resolution crystal structures of human Rab4a in its active and inactive conformations Fulltext Access 9 Pages 2005
Modulating furin activity with designed mini-PDX peptides: Synthesis and in vitro kinetic evaluation Fulltext Access 9 Pages 2005
GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa Fulltext Access 9 Pages 2005
Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats Fulltext Access 9 Pages 2005
Trifluoromethyl group as a pharmacophore: Effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand Fulltext Access 9 Pages 2005
Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells Fulltext Access 9 Pages 2005
Pepsinogen and H,K-ATPase mediate acid secretion in gastric glands of Triturus carnifex (Amphibia, Caudata) Fulltext Access 9 Pages 2005
Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users Fulltext Access 9 Pages 2005
Myosin heavy chain isoform immunolabelling in diabetic rats with peripheral neuropathy Fulltext Access 9 Pages 2005
Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis Fulltext Access 9 Pages 2005
Abstracts: 24th Annual Meeting of the Israel Society for Histochemistry and Cytochemistry held in Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel, on 1 June 2005 Fulltext Access 9 Pages 2005
Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells Fulltext Access 9 Pages 2005
A novel approach to study adhesion mechanisms by isolation of the interacting system Fulltext Access 9 Pages 2005
The protective effects of melatonin against water avoidance stress-induced mast cell degranulation in dermis Fulltext Access 9 Pages 2005
Loss of PNA staining in mouse aortico-pulmonary septum is associated with mesenchymal cell apoptosis Fulltext Access 9 Pages 2005
Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins Fulltext Access 9 Pages 2005
In vivo protection of synaptosomes from oxidative stress mediated by Fe2+/H2O2 or 2,2-azobis-(2-amidinopropane) dihydrochloride by the glutathione mimetic tricyclodecan-9-yl-xanthogenate Fulltext Access 9 Pages 2005
ROS mediates 4HPR-induced posttranscriptional expression of the Gadd153 gene Fulltext Access 9 Pages 2005
4-Hydroxynonenal increases γ-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways Fulltext Access 9 Pages 2005
Oxidized low-density lipoprotein elicits an intracellular calcium rise and increases the binding activity of the transcription factor NFAT Fulltext Access 9 Pages 2005
RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles Fulltext Access 9 Pages 2005
Molecular characterization of the first satellite DNA with CENP-B and CDEIII motifs in the bat Pipistrellus kuhli Fulltext Access 9 Pages 2005
Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1 Fulltext Access 9 Pages 2005
The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding Fulltext Access 9 Pages 2005
SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1 Fulltext Access 9 Pages 2005
Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H-naphtho[1,2,3-de]quinoline, and 7-oxo-7H-benzo[e]perimidine Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study Fulltext Access 9 Pages 2005
3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases Fulltext Access 9 Pages 2005
Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons Fulltext Access 9 Pages 2005
Oligonucleotides containing 2′-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation Fulltext Access 9 Pages 2005
Design and synthesis of low molecular weight compounds with complement inhibition activity Fulltext Access 9 Pages 2005
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity Fulltext Access 9 Pages 2005
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities Fulltext Access 9 Pages 2005
Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologues Fulltext Access 9 Pages 2005
Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity Fulltext Access 9 Pages 2005
Semisynthesis and biological activity of aminoacyl triesters of squamocin, an annonaceous acetogenin Fulltext Access 9 Pages 2005
Synthesis, in vitro, and in vivo characterization of an integrin αvβ3-targeted molecular probe for optical imaging of tumor Fulltext Access 9 Pages 2005
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin Fulltext Access 9 Pages 2005
Design, syntheses, and biological evaluations of squamostolide and its related analogs Fulltext Access 9 Pages 2005
Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds Fulltext Access 9 Pages 2005
Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives Fulltext Access 9 Pages 2005
Antiviral cyclic d,l-α-peptides: Targeting a general biochemical pathway in virus infections Fulltext Access 9 Pages 2005
Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist Fulltext Access 9 Pages 2005
8-O-Azeloyl-14-benzoylaconine: A new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities Fulltext Access 9 Pages 2005
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives Fulltext Access 9 Pages 2005
Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens Fulltext Access 9 Pages 2005
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents Fulltext Access 9 Pages 2005
Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides Fulltext Access 9 Pages 2005
Design and synthesis of glycosidase inhibitor 5-amino-1,2,3,4-cyclohexanetetrol derivatives from (−)-vibo-quercitol Fulltext Access 9 Pages 2005
Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators Fulltext Access 9 Pages 2005
3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation Fulltext Access 9 Pages 2005
Modeling Km values using electrotopological state: Substrates for cytochrome P450 3A4-mediated metabolism Fulltext Access 9 Pages 2005
[11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents Fulltext Access 9 Pages 2005
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Fulltext Access 9 Pages 2005
Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles Fulltext Access 9 Pages 2005
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines Fulltext Access 9 Pages 2005
Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids Fulltext Access 9 Pages 2005
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers Fulltext Access 9 Pages 2005
Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities Fulltext Access 9 Pages 2005
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter Fulltext Access 9 Pages 2005
Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity Fulltext Access 9 Pages 2005
Radical scavenging activity of dicaffeoyloxycyclohexanes: Contribution of an intramolecular interaction of two caffeoyl residues Fulltext Access 9 Pages 2005
A quantitative structure-activity relationship study on some series of anthranilic acid-based matrix metalloproteinase inhibitors Fulltext Access 9 Pages 2005
Hypocholesterolemic effects of phenolic-rich extracts of Chemlali olive cultivar in rats fed a cholesterol-rich diet Fulltext Access 9 Pages 2005
Bridge-linked bis-quaternary ammonium anti-microbial agents: relationship between cytotoxicity and anti-bacterial activity of 5,5′-[2,2′-(tetramethylenedicarbonyldioxy)-diethyl]bis(3-alkyl-4-methylthiazonium iodide)s Fulltext Access 9 Pages 2005
Porphyrin substituted phosphoramidites: new building blocks for porphyrin–oligonucleotide syntheses Fulltext Access 9 Pages 2005
Quantitative structure–activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds Fulltext Access 9 Pages 2005