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Pharmacology Research Articles

Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells
Fulltext Access 6 Pages 2008
Induction of late airway response was involved in serum antigen-specific immunoglobulin G in rats
Fulltext Access 6 Pages 2008
Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock
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Meglumine antimonate directly increases phagocytosis, superoxide anion and TNF-α production, but only via TNF-α it indirectly increases nitric oxide production by phagocytes of healthy individuals, in vitro
Fulltext Access 6 Pages 2008
An anti-sepsis monomer, 2′,5,6′,7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo
Fulltext Access 6 Pages 2008
Immunopotentiation of Caffeoyl Glycoside from Picrorhiza scrophulariiflora on activation and cytokines secretion of immunocyte in vitro
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Protective effect of Misgurnus anguillicaudatus polysaccharide on immunological liver injury in mice
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RETRACTED: Roxithromycin inhibits the effector phase of delayed-type hypersensitivity
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Inhibitory effect of siRNA targeting survivin in gastric cancer MGC-803 cells
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Modulation of the immune response using Rapana thomasiana hemocyanin
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Preliminary exploration on anti-inflammatory mechanism of Corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) in vitro
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Prostaglandin-induced VASP phosphorylation controls αII-spectrin breakdown in apoptotic cells
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PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia
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The natural prenylated flavone artelastin is an inhibitor of ROS and NO production
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Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine
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Induction of cytolytic activity and interferon-γ production in murine natural killer cells by polymyxins B and E
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Ca2+ signalling of kinins in cells expressing rat, mouse and human B1/B2-receptor
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Roles of the kallikrein/kinin system in the adaptive immune system
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Tissue specific expression of angiotensin converting enzyme: A new way to study an old friend
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Loss of glycinergic and GABAergic inhibition in chronic pain—contributions of inflammation and microglia
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Modulation of B1 and B2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy
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Kininogen binding to the surfaces of macrophages
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Modulation by bradykinin and nitric oxide of angiotensin II-induced apoptosis in a vascular smooth muscle cell phenotype
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Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers
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Fructose-1,6-diphosphate attenuates acute lung injury induced by lipopolysaccharide in mice
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Signaling pathway for TNF-α-induced MMP-9 expression: Mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells
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Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice
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Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune responses in vivo
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Protective effect of apigenin on ovariectomy-induced bone loss in rats
Fulltext Access 7 Pages 2008
Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells
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Angiotensin II-induced vasodilation via type 2 receptor: Role of bradykinin and nitric oxide
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Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma
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Lycopene attenuates diabetes-associated cognitive decline in rats
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Functional assessment of angiotensin II and bradykinin analogues containing the paramagnetic amino acid TOAC
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Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins
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Sustained release of corticosterone in rats affects reactivity, but does not affect habituation to immobilization and acoustic stimuli
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Effect of aging on 24-hour pattern of stress hormones and leptin in rats
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Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats
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Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae
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Interleukin-1β-mediated inhibition of the processes of angiogenesis in cardiac microvascular endothelial cells
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Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion
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The toxicity of β-amyloid is attenuated by interaction with its specific human scFv E3 in vitro
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Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro
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Predominant role of 25OHD in the negative regulation of PTH expression: Clinical relevance for hypovitaminosis D
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T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin–NFAT3 activation as well as L-type Ca2+ channel blockers
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Blood pressure measurement with the tail-cuff method in Wistar and spontaneously hypertensive rats: Influence of adrenergic- and nitric oxide-mediated vasomotion
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Co-localization of glucocorticoid metabolizing and prostaglandin synthesizing enzymes in rat kidney and liver
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In vivo trafficking of endogenous opioid receptors
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Aging-related changes of QT and RR intervals in conscious guinea pigs
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A dual-labeling method to quantify unscheduled DNA synthesis in primary cells
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Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of humanized monoclonal anti-IL-13 antibodies with different IL-13 neutralization mechanisms
Fulltext Access 7 Pages 2008
Mechanical hyperalgesia is attenuated by local administration of octreotide in pristane-induced arthritis in Dark-Agouti rats
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Involvement of altered arginase activity, arginase I expression and NO production in accelerated intimal hyperplasia following cigarette smoke extract
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Use of a portable thermal imaging unit as a rapid, quantitative method of evaluating inflammation and experimental arthritis
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Melatonin prevents amyloid protofibrillar induced oxidative imbalance and biogenic amine catabolism
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Effect of buffer components and carrier solvents on in vitro activity of recombinant human carboxylesterases
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A microscopic technique to study kinetics and concentration–response of drug-induced caspase-3 activation on a single cell level
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Biomarkers in drug discovery and development
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Lichen metabolites prevent UV light and nitric oxide-mediated plasmid DNA damage and induce apoptosis in human melanoma cells
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The potential role of carbon dioxide in the neuroimmunoendocrine changes following cerebral ischemia
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Differential regulation of 11β-hydroxysteroid dehydrogenase type-1 and -2 gene transcription by proinflammatory cytokines in vascular smooth muscle cells
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Role of VR1 and CB1 receptors in modelling of cardio-respiratory response to arvanil, an endocannabinoid and vanilloid hybrid, in rats
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Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma
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Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice
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Protective role of ascorbic acid isolated from Cissus quadrangularis on NSAID induced toxicity through immunomodulating response and growth factors expression
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Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde
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Studies on pharmacological effects of Russell's viper and Saw-scaled viper venom and its neutralization by chicken egg yolk antibodies
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Genistein down-modulates pro-inflammatory cytokines and reverses clinical signs of experimental autoimmune encephalomyelitis
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Differential gene expression in murine large cell B-cell lymphoma metastatic variants
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Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice
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Cancer immunotherapeutic effects of novel CpG ODN in murine tumor model
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Anti-tumor and immunomodulating activities of proteoglycans from mycelium of Phellinus nigricans and culture medium
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Fucoidan stimulation induces a functional maturation of human monocyte-derived dendritic cells
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Inhibitory effects of parthenolide on antigen-induced microtubule formation and degranulation in mast cells
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Development of a novel method to measure macrophage migration inhibitory factor (MIF) in sera of patients with rheumatoid arthritis by combined electrochemical immunosensor
Fulltext Access 7 Pages 2008
Identification and characterization of nonapeptide targeting a human B cell lymphoma, Raji
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Effect of oral immunomodulator Dzherelo in TB/HIV co-infected patients receiving anti-tuberculosis therapy under DOTS
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Heme oxygenase-1 upregulation significantly inhibits TNF-α and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice
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A synthetic cyclic peptide derived from Limulus anti-lipopolysaccharide factor neutralizes endotoxin in vitro and in vivo
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Diterpenes drive Th1 polarization depending on IL-12
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Anti-IL-6 receptor antibody increases blood IL-6 level via the blockade of IL-6 clearance, but not via the induction of IL-6 production
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(–)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis
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Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats
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New perspective on the tissue kallikrein–kinin system in myocardial infarction: Role of angiogenesis and cardiac regeneration
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Selenium suppresses the activation of transcription factor NF-κB and IRF3 induced by TLR3 or TLR4 agonists
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Enhancement of anti-inflammatory property of aspirin in mice by a nano-emulsion preparation
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Lactic acid bacteria inhibit proinflammatory cytokine expression and bacterial glycosaminoglycan degradation activity in dextran sulfate sodium-induced colitic mice
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Differential anti-inflammatory pathway by xanthohumol in IFN-γ and LPS-activated macrophages
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Warifteine, a bisbenzylisoquinoline alkaloid, decreases immediate allergic and thermal hyperalgesic reactions in sensitized animals
Fulltext Access 7 Pages 2008
Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2, 7-dimethyl-3-nitro-4H pyrido [1,2-a] pyrimidine-4-one
Fulltext Access 7 Pages 2008
Effects of florfenicol on early cytokine responses and survival in murine endotoxemia
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Expression of angiotensin I-converting enzymes and bradykinin B2 receptors in mouse inner medullary-collecting duct cells
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Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression
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Continued inhalation of lidocaine suppresses antigen-induced airway hyperreactivity and airway inflammation in ovalbumin-sensitized guinea pigs
Fulltext Access 7 Pages 2008
Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers
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17β-Estradiol enhances expression of inflammatory cytokines and inducible nitric oxide synthase in mouse contact hypersensitivity
Fulltext Access 7 Pages 2008
Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats
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Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation
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Baculovirus up-regulates antiviral systems and induces protection against infectious bronchitis virus challenge in neonatal chicken
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Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs
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