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Pharmacology Research Articles

Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat
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Intraperitoneal leptin regulates lipid metabolism in ethanol supplemented Mus musculas heart
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Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats
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Aceclidine and pilocarpine interact differently with muscarinic receptor in isolated rabbit iris muscle
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Comparison of opioid receptor distributions in the rat ileum
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Hypothalamic 5-HT functional regulation through 5-HT1A and 5-HT2C receptors during pancreatic regeneration
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Vascular and renal effects of dopamine during extracellular volume expansion: Role of nitric oxide pathway
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Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats
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Mycophenolic acid inhibits mesangial cell activation through p38 MAPK inhibition
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Evaluation of antioxidant activity and potential toxicity of 1-buthyltelurenyl-2-methylthioheptene
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Decreased α2-adrenergic receptor in the brain stem and pancreatic islets during pancreatic regeneration in weanling rats
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Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma
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NAD(P)H oxidase-stimulating activity of serum from type 2 diabetic patients with retinopathy mediates enhanced endothelial expression of E-selectin
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Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers: Cell density-dependent effects prevented by sulfation
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Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD14 and TLR-4 receptor activation in human gingival fibroblasts
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Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia–reperfusion in mice
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COX-2 mediates morphine-induced delayed cardioprotection via an iNOS-dependent mechanism
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Hormones in the nucleus. Immunologically demonstrable biogenic amines (serotonin, histamine) in the nucleus of rat peritoneal mast cells
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Dominant-negative Rac1 suppresses Ras-induced apoptosis possibly through activation of NFκB in Ha-ras oncogene-transformed NIH/3T3 cells
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Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin
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Up-regulation of integrin-linked kinase activity in rat mesangioproliferative glomerulonephritis
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Diazepam effects on Ehrlich tumor growth and macrophage activity in mice
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Up-regulated l-type high voltage-gated calcium channels cause increase in diazepam binding inhibitor induced by sustained morphine exposure in mouse cerebrocortical neurons
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Expression of isoforms of NADPH oxidase components in rat pancreatic islets
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The ascochlorin derivative, AS-6, inhibits TNF-α-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells
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Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5′-flanking sequence of the mouse 4E-BP1 gene
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Effects of DK-002, a synthesized (6aS,cis)-9,10-Dimethoxy-7,11b-dihydro-indeno[2,1-c]chromene-3,6a-diol, on platelet activity
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Effects of streptozotocin-induced diabetes and insulin on calcium responsiveness of the rat vas deferens
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Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: Clinical evidence in thyroidectomized subjects on thyroxine replacement therapy
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Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes
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Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice
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Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats
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Neuronal expression of nuclear transcription factor MafG in the rat medulla oblongata after baroreceptor stimulation
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Caffeic acid phenethyl ester ameliorates changes in IGFs secretion and gene expression in streptozotocin-induced diabetic rats
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Effect of chronic social stress on nitric oxide synthesis and vascular function in rats with family history of hypertension
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Effect of ischemic preconditioning on cerebral blood flow after subsequent lethal ischemia in gerbils
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Role of caspases in acetaminophen-induced liver injury
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Dynamics of progestogenic activity in serum following administration of Ligusticum chuanxiong
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Establishment of ex vivo systems to identify compounds acting on innate immune responses and to determine their target molecules using transgenic Drosophila
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Multiple biological activities of curcumin: A short review
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Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract
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Dietary supplements and related products: A brief summary
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Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway
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Inhibitory effect of Curcuma comosa on NO production and cytokine expression in LPS-activated microglia
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Effect of indole acetic acid administration on the neutrophil functions and oxidative stress from neutrophil, mesenteric lymph node and liver
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Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats
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Gastroprotective and ulcer healing effect of ferruginol in mice and rats: Assessment of its mechanism of action using in vitro models
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SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
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Myocardial infarction increases reactivity to phenylephrine in isolated aortic rings of ovariectomized rats
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Lewis and Fischer 344 strain differences in α2-adrenoceptors and tyrosine hydroxylase expression
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Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
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Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells
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Angiotensin II type 1 (AT1)-receptor blocker prevents impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats
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Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-α-induced IL-8 secretion in the human airway epithelial cell line NCI-H292
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Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice
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Cloning of a novel human caspase-9 splice variant containing only the CARD domain
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Metoprolol reduces ‘compensatory’ coronary blood flow following occlusion of an adjacent branch without altering post-occlusion hyperaemia
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Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: Interactions with α1-, 5-HT2- and H1-receptors
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Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E2 production in murine macrophage RAW 264.7 cells
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Expression of glucocorticoid receptor in the intestine of a euryhaline teleost, the Mozambique tilapia (Oreochromis mossambicus): Effect of seawater exposure and cortisol treatment
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Action of imipramine on activated ATP-sensitive K+ channels in interstitial cells of Cajal from murine small intestine
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Effect of selenium-enriched malt on hepatocarcinogenesis, paraneoplastic syndrome and the hormones regulating blood glucose in rats treated by diethylnitrosamine
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Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia
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Role of lupeol and lupeol linoleate on lipemic–oxidative stress in experimental hypercholesterolemia
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In vitro effect of the potent poly(ADP-ribose) polymerase (PARP) inhibitor INO-1001 alone and in combination with aspirin, eptifibatide, tirofiban, enoxaparin or alteplase on haemostatic parameters
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Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria
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Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice
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Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid
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Gene expression of transforming growth factor-β receptors types I and II in rat endometrium during the estrous cycle and early pregnancy
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Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action
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The regulatory mechanism of Tremella mesenterica on steroidogenesis in MA-10 mouse Leydig tumor cells
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Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice
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5-HT2 receptor blocker sarpogrelate prevents downregulation of antiapoptotic protein Bcl-2 and protects the heart against ischemia–reperfusion injury
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Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes
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Purification and characterization of neuropathy target esterase (NTE) from rat brain
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Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior
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Antivasoconstrictor effect of the neuroprotective agent dexrazoxane in rat aorta
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Transgene expression of biological active recombinant human granulocyte-colony stimulating factor (hG-CSF) into mouse urine
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Effect of chitooligosaccharides on calcium bioavailability and bone strength in ovariectomized rats
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Role of angiotensin II receptor subtypes in porcine basilar artery: Functional, radioligand binding, and cell culture studies
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Characterisation of CGRP receptors in the human isolated middle meningeal artery
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Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors
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Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats
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Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs
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No change in cortical muscarinic M2, M3 receptors or [35S]GTPγS binding in schizophrenia
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Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats
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Partial agonistic effect of 9-hydroxycorynantheidine on μ-opioid receptor in the guinea-pig ileum
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Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6
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Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats
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Structure-activity relationship between carboxylic acids and T cell cycle blockade
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(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation
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Effects of second generation tetracyclines on penicillin-epilepsy-induced hippocampal neuronal loss and motor incoordination in rats
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Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy
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Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis
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Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver
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Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with l-[β-11C]DOPA
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Increases in transepithelial vectorial Na+ transport facilitates Na+-dependent l-DOPA transport in renal OK cells
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Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes
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Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats
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Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits
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