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Pharmacology Research Articles

Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists
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N-[2-(m-methoxyphenyl)ethyl]-N-ethyl-2-(1-pyrrolidinyl)ethylamine (UMB 116) is a novel antagonist for cocaine-induced effects
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Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells
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Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization
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Functional expression of the P2Y14 receptor in human neutrophils
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Inhibitory effect of chroman carboxamide on interleukin-6 expression in response to lipopolysaccharide by preventing nuclear factor-κB activation in macrophages
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Acetaminophen-induced toxicity is prevented by β-d-glucan treatment in mice
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Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload
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Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
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Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus
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Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone
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Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice
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Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine
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Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation
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Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells
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Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species
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Predicting Alzheimer dementia in mild cognitive impairment patients: Are biomarkers useful?
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Pathways of neurodegeneration and experimental models of basal ganglia disorders: Downstream effects of mitochondrial inhibition
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Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness
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Effect of anandamide on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum
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Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats
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Classical as well as novel antipsychotic drugs increase self-stimulation threshold in the rat — Similar mechanism of action?
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Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats
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Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-κB through Akt and p38 inhibition in RAW 264.7 macrophage cells
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N-hexacosanol reverses diabetic induced muscarinic hypercontractility of ileum in the rat
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Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation
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Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats
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Enhanced neuropeptide Y immunoreactivity and vasoconstriction in mesenteric small arteries from the early non-obese diabetic mouse
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Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin–nitrite–H2O2 induced liver injury
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Effect of YM-254890, a specific Gαq/11 inhibitor, on experimental peripheral arterial disease in rats
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Effects of dextrorotatory morphinans on α3β4 nicotinic acetylcholine receptors expressed in Xenopus oocytes
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SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue
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Vascular endothelin ETB receptor-mediated contraction requires phosphorylation of ERK1/2 proteins
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Carboxyamido-triazole inhibits proliferation of human breast cancer cells via G2/M cell cycle arrest and apoptosis
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NH4+ modulates renal tubule amantadine transport independently of intracellular pH changes
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Molecular diversity of voltage-gated sodium channel α and β subunit mRNAs in human tissues
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Carboxymethyl-chitosan protects rabbit chondrocytes from interleukin-1β-induced apoptosis
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Cannabinoid signalling in TNF-α induced IL-8 release
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Characterisation of the relaxant response to raloxifene in porcine coronary arteries
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Temporal profile of forced expiratory lung function in allergen-challenged Brown–Norway rats
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Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs
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Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure
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Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice
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Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals
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The prooxidant, rather than antioxidant, acts of daidzein in vivo and in vitro: Daidzein suppresses glutathione metabolism
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Anti-oxidant sensitivity of donor age-related gene expression in cultured fibroblasts
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Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioning
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Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment
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Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum
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Isoflurane preconditioning protects human neuroblastoma SH-SY5Y cells against in vitro simulated ischemia-reperfusion through the activation of extracellular signal-regulated kinases pathway
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Structure–activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: Comparison between subclasses of flavonoids
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Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts: The measurements of cellular Ca2+ and nitric oxide release
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Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy
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The selective effect of cystathionine on doxorubicin hepatotoxicity in tumor-bearing mice
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Keyword index
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Azithromycin has a direct relaxant effect on precontracted airway smooth muscle
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Impact of chronic β-adrenoceptor activation on neurotensin-induced myocardial effects in rats
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Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat
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Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration
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Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation
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Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning
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Fenretinide inhibits HIV infection by promoting viral endocytosis
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Protective effect of CardiPro against doxorubicin-induced cardiotoxicity in mice
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Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle
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In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARγ in L6 myotubes
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Multitarget therapy – The future of treatment for more than just functional dyspepsia
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Phytotherapy for functional dyspepsia: A review of the clinical evidence for the herbal preparation STW 5
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Spasmolytic and tonic effect of Iberogast® (STW 5) in intestinal smooth muscle
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Pharmaceutical prerequisites for a multi-target therapy
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Electrophysiological effects of the aqueous extract of Averrhoa carambola L. leaves on the guinea pig heart
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Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay
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Native Kenyan plants as possible alternatives to methyl bromide in soil fumigation
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Antihyperglycemic activity of Tarralin™, an ethanolic extract of Artemisia dracunculus L.
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Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats
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Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats
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Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation
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Changes in mGlu5 receptor expression in the basal ganglia of reserpinised rats
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Influence of external and intracellular pH on propofol-induced responses in rat locus coeruleus neurons
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Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
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Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models
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Differential effects of hydroxyacetophenone analogues on the transcytotic vesicular pathway in rat liver
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Effects of chronic ethanol administration on brain protein levels: A proteomic investigation using 2-D DIGE system
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Neurosteroid modulation of recombinant rat α5β2γ2L and α1β2γ2L GABAA receptors in Xenopus oocyte
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Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice
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Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells
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Cognitive dysfunction induced by sequential injection of amyloid-β and ibotenate into the bilateral hippocampus; protection by memantine and MK-801
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Blockade of Ca2+-activated K+ channels by galantamine can also contribute to the potentiation of catecholamine secretion from chromaffin cells
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Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor
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Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells
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Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein
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Altered hippocampal gene expression 2 days after general anesthesia in rats
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Involvement of μ-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa
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Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells
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In vitro and in vivo antitumour effects of novel, orally active bile acid-conjugated platinum complexes on rat hepatoma
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Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
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Selection of new chemical entities with decreased potential for adverse drug reactions
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Absorption of folate by Caco-2 cells is not affected by high glucose concentration
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SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition
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Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism
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Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat
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