Does the cell wall of bacteria remain a viable source of targets for novel antibiotics? Fulltext Access 10 Pages 2006
The historical delivery of antibiotics from microbial natural products—Can history repeat? Fulltext Access 10 Pages 2006
Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes Fulltext Access 10 Pages 2006
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: A kinetic analysis Fulltext Access 10 Pages 2006
Pharmacological characterization of protease activated receptor-1 by a serum responsive element-dependent reporter gene assay: Major role of calmodulin Fulltext Access 10 Pages 2006
Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells Fulltext Access 10 Pages 2006
Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1 Fulltext Access 10 Pages 2006
Diverse signalling by different chemokines through the chemokine receptor CCR5 Fulltext Access 10 Pages 2006
Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps Fulltext Access 10 Pages 2006
Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide Fulltext Access 10 Pages 2006
Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice Fulltext Access 10 Pages 2006
Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors Fulltext Access 10 Pages 2006
14-3-3ζ interacts with human thromboxane receptors and is involved in the agonist-induced activation of the extracellular-signal-regulated kinase Fulltext Access 10 Pages 2006
Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes Fulltext Access 10 Pages 2006
Peptide-bond modified glutathione conjugate analogs modulate GSTπ function in GSH-conjugation, drug sensitivity and JNK signaling Fulltext Access 10 Pages 2006
Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling Fulltext Access 10 Pages 2006
Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines Fulltext Access 10 Pages 2006
STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I Fulltext Access 10 Pages 2006
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells Fulltext Access 10 Pages 2006
Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors Fulltext Access 10 Pages 2006
Characterisation of CGRP receptors in human and porcine isolated coronary arteries: Evidence for CGRP receptor heterogeneity Fulltext Access 10 Pages 2006
Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine Fulltext Access 10 Pages 2006
Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis Fulltext Access 10 Pages 2006
Effect of orally administered rolipram, a phosphodiesterase 4 inhibitor, on a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application Fulltext Access 10 Pages 2006
Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT7 serotonin receptor Fulltext Access 10 Pages 2006
The use of low dose methotrexate in rheumatoid arthritis—are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Fulltext Access 10 Pages 2006
Benign, atypical and malignant lymphoproliferative disorders in rheumatoid arthritis patients Fulltext Access 10 Pages 2006
Transport and metabolism of cyclosporine in isolated rat hepatocytes: The effects of lipids Fulltext Access 10 Pages 2006
Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity Fulltext Access 10 Pages 2006
XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: Role of ERCC1 in homologous recombination repair Fulltext Access 10 Pages 2006
Dual-acting diamine antiplasmodial and chloroquine resistance modulating agents Fulltext Access 10 Pages 2006
Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors Fulltext Access 10 Pages 2006
Potencies of topical glucocorticoids to mediate genomic and nongenomic effects on human peripheral blood mononuclear cells Fulltext Access 10 Pages 2006
Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide Fulltext Access 10 Pages 2006
Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: In vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae Fulltext Access 10 Pages 2006
Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro Fulltext Access 10 Pages 2006
Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice Fulltext Access 10 Pages 2006
Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1 Fulltext Access 10 Pages 2006
Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells Fulltext Access 10 Pages 2006
Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria Fulltext Access 10 Pages 2006
Use of constraint-based modeling for the prediction and validation of antimicrobial targets Fulltext Access 10 Pages 2006
The adrenergic α2 receptor and sexual incentive motivation in male rats Fulltext Access 10 Pages 2006
Role of pharmacologically active metabolites in drug discovery and development Fulltext Access 10 Pages 2006
Vascular NADPH oxidases as drug targets for novel antioxidant strategies Fulltext Access 10 Pages 2006
R&D technology investments: misguided and expensive or a better way to discover medicines? Fulltext Access 10 Pages 2006
Methylphenidate and cocaine: A placebo-controlled drug interaction study Fulltext Access 10 Pages 2006
Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic–pituitary–adrenal axis Fulltext Access 10 Pages 2006
Plastic neuronal changes in GABAA receptor gene expression induced by progesterone metabolites: In vitro molecular and functional studies Fulltext Access 10 Pages 2006
Stacking anabolic androgenic steroids (AAS) during puberty in rats: A neuroendocrine and behavioral assessment Fulltext Access 10 Pages 2006
Effect of bupropion on physiological measures of stress in smokers during nicotine withdrawal Fulltext Access 10 Pages 2006
The role of delta opioid receptors in the anxiolytic actions of benzodiazepines Fulltext Access 10 Pages 2006
Early deprivation increases exploration and locomotion in adult male Wistar offspring Fulltext Access 10 Pages 2006
Stability of cocaine dose–response functions at different inter-dose intervals Fulltext Access 10 Pages 2006
MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users Fulltext Access 10 Pages 2006
Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats Fulltext Access 10 Pages 2006
Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner Fulltext Access 10 Pages 2006
Effects of acute and chronic ethanol exposure on the behavior of adult zebrafish (Danio rerio) Fulltext Access 10 Pages 2006
Antinociceptive properties of the ethanolic extract and of the triterpene 3β,6β,16β-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice Fulltext Access 10 Pages 2006
Nociceptive stimulus modality-related difference in pharmacokinetic–pharmacodynamic modeling of morphine in the rat Fulltext Access 10 Pages 2006
Intravenous methamphetamine self-administration in rats: Effects of intravenous or intraperitoneal MDMA co-administration Fulltext Access 10 Pages 2006
STW 5 (Iberogast®) and its individual herbal components modulate intestinal electrophysiology of mice Fulltext Access 10 Pages 2006
Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-κB and AP-1 as prime targets Fulltext Access 10 Pages 2006
Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (−)-epigallocatechin-3-gallate, a polyphenol component of green tea Fulltext Access 10 Pages 2006
The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase Fulltext Access 10 Pages 2006
Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein Fulltext Access 10 Pages 2006
R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: Partial involvement of the CB2 Fulltext Access 10 Pages 2006
Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1 Fulltext Access 10 Pages 2006
The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase Fulltext Access 10 Pages 2006
Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases Fulltext Access 10 Pages 2006
Herbal melanin modulates tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production Fulltext Access 10 Pages 2006
Region-specific effects of STW 5 (Iberogast®) and its components in gastric fundus, corpus and antrum Fulltext Access 10 Pages 2006
A mathematical theory for temporal changes in tolerance to the behavioral effects of alcohol Fulltext Access 10 Pages 2006
Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic–pituitary–adrenal axis Fulltext Access 10 Pages 2006
Improvement of accessory symptoms of hypertension by TSUMURA Orengedokuto Extract, a four herbal drugs containing Kampo-Medicine Granules for ethical use: A double-blind, placebo-controlled study Fulltext Access 10 Pages 2006
Expression of CXC chemokine receptors 1–5 and their ligands in human glioma tissues: Role of CXCR4 and SDF1 in glioma cell proliferation and migration Fulltext Access 10 Pages 2006
Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury Fulltext Access 10 Pages 2006
Beyond interferon and ribavirin: Antiviral therapies for hepatitis C virus Fulltext Access 10 Pages 2006
Immune response modifiers: Imiquimod and future drugs for modulating the immune response Fulltext Access 10 Pages 2006
Development and validation of novel imaging technologies to assist translational studies in atherosclerosis Fulltext Access 10 Pages 2006