Control of cellular proliferation by modulation of oxidative phosphorylation in human and rodent fast-growing tumor cells Fulltext Access 10 Pages 2006
3α-6α-Dihydroxy-7α-fluoro-5β-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17α-ethynyl-estradiol-induced cholestasis in rats Fulltext Access 10 Pages 2006
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice Fulltext Access 10 Pages 2006
Benzo[a]pyrene and glycine N-methyltransferse Interactions: Gene expression profiles of the liver detoxification pathway Fulltext Access 10 Pages 2006
Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity Fulltext Access 10 Pages 2006
4-Hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells Fulltext Access 10 Pages 2006
Energy metabolism and biotransformation as endpoints to pre-screen hepatotoxicity using a liver spheroid model Fulltext Access 10 Pages 2006
Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism Fulltext Access 10 Pages 2006
Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C Fulltext Access 10 Pages 2006
Altered expression of connexin43 in the inhibition of gap junctional intercellular communication by chlorohydroxyfuranones in WB-F344 rat liver epithelial cells Fulltext Access 10 Pages 2006
Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine Fulltext Access 10 Pages 2006
Molecular mechanisms underlying mancozeb-induced inhibition of TNF-alpha production Fulltext Access 10 Pages 2006
Up-regulation of cytosolic phospholipase A2α expression by N,N-diethyldithiocarbamate in PC12 cells; involvement of reactive oxygen species and nitric oxide Fulltext Access 10 Pages 2006
The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers Fulltext Access 10 Pages 2006
Activation of peroxisome proliferator-activated receptor-γ (PPARγ) induces cell death through MAPK-dependent mechanism in osteoblastic cells Fulltext Access 10 Pages 2006
CD28 in thymocyte development and peripheral T cell activation in mice exposed to suspended particulate matter Fulltext Access 10 Pages 2006
Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts Fulltext Access 10 Pages 2006
Estrogenic compounds inhibit gap junctional intercellular communication in mouse Leydig TM3 cells Fulltext Access 10 Pages 2006
Responses of well-differentiated nasal epithelial cells exposed to particles: Role of the epithelium in airway inflammation Fulltext Access 10 Pages 2006
Differentiation of the roles of NO from airway epithelium and inflammatory cells in ozone-induced lung inflammation Fulltext Access 10 Pages 2006
Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate Fulltext Access 10 Pages 2006
A sea urchin lectin, SUL-1, from the Toxopneustid sea urchin induces DC maturation from human monocyte and drives Th1 polarization in vitro Fulltext Access 10 Pages 2006
Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites Fulltext Access 10 Pages 2006
p38 mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes Fulltext Access 10 Pages 2006
Cystine alters the renal and hepatic disposition of inorganic mercury and plasma thiol status Fulltext Access 10 Pages 2006
Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice Fulltext Access 10 Pages 2006
DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: Involvement of the oxidative mechanism Fulltext Access 10 Pages 2006
A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat Fulltext Access 10 Pages 2006
Mechanism of apoptosis induced by a polysaccharide, from the loach Misgurnus anguillicaudatus (MAP) in human hepatocellular carcinoma cells Fulltext Access 10 Pages 2006
Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide Fulltext Access 10 Pages 2006
A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response Fulltext Access 10 Pages 2006
Effects of the differentiated keratinocyte phenotype on expression levels of CYP1–4 family genes in human skin cells Fulltext Access 10 Pages 2006
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity Fulltext Access 10 Pages 2006
Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line Fulltext Access 10 Pages 2006
The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat Fulltext Access 10 Pages 2006
Co-cultivation of Streptomyces californicus and Stachybotrys chartarum stimulates the production of cytostatic compound(s) with immunotoxic properties Fulltext Access 10 Pages 2006
The coffee diterpene kahweol inhibits tumor necrosis factor-α-induced expression of cell adhesion molecules in human endothelial cells Fulltext Access 10 Pages 2006
Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes Fulltext Access 10 Pages 2006
Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene Fulltext Access 10 Pages 2006
In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)α and PPARγ and quantitative analysis of in vivo induction pathway Fulltext Access 10 Pages 2006
Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma Fulltext Access 10 Pages 2006
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS Fulltext Access 10 Pages 2006
T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis Fulltext Access 10 Pages 2006
Differential effects of pyrethroid insecticides on extracellular dopamine in the striatum of freely moving rats Fulltext Access 10 Pages 2006
Regional specificity in deltamethrin induced cytochrome P450 expression in rat brain Fulltext Access 10 Pages 2006
Pyrethroid pesticide-induced alterations in dopamine transporter function Fulltext Access 10 Pages 2006
Cardiotoxicity of copper-based antineoplastic drugs casiopeinas is related to inhibition of energy metabolism Fulltext Access 10 Pages 2006
Isolation and characterization of two disintegrins inhibiting ADP-induced human platelet aggregation from the venom of Crotalus scutulatus scutulatus (Mohave Rattlesnake) Fulltext Access 10 Pages 2006
Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide Fulltext Access 10 Pages 2006
Biochemical mechanism of insulin sensitization, lipid modulation and anti-atherogenic potential of PPAR α/γ dual agonist: Ragaglitazar Fulltext Access 10 Pages 2006
Melatonin directly scavenges free radicals generated in red blood cells and a cell-free system: Chemiluminescence measurements and theoretical calculations Fulltext Access 10 Pages 2006
Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats Fulltext Access 10 Pages 2006
Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats Fulltext Access 10 Pages 2006
Optimal compressive force induces bone formation via increasing bone morphogenetic proteins production and decreasing their antagonists production by Saos-2 cells Fulltext Access 10 Pages 2006
Cellular action of cholecystokinin-8S-mediated excitatory effects in the rat periaqueductal gray Fulltext Access 10 Pages 2006
Selective cytotoxicity of withaphysalins in myeloid leukemia cell lines versus peripheral blood mononuclear cells Fulltext Access 10 Pages 2006
Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation Fulltext Access 10 Pages 2006
Monitoring the gene expression profiles of doxorubicin-resistant acute myelocytic leukemia cells by DNA microarray analysis Fulltext Access 10 Pages 2006
Inhibition of intestinal glucose uptake by aporphines and secoaporphines Fulltext Access 10 Pages 2006
Sodium as the major mediator of NO-induced cell death in cultured hepatocytes Fulltext Access 10 Pages 2006
Identification of avarol derivatives as potential antipsoriatic drugs using an in vitro model for keratinocyte growth and differentiation Fulltext Access 10 Pages 2006
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia Fulltext Access 10 Pages 2006
Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells Fulltext Access 10 Pages 2006
Reactive oxygen species scavenging capacity of different cooked garlic preparations Fulltext Access 10 Pages 2006
Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval Fulltext Access 10 Pages 2006
Can optical recordings of membrane potential be used to screen for drug-induced action potential prolongation in single cardiac myocytes? Fulltext Access 10 Pages 2006
A model of orthostatic hypotension in the conscious monkey using lower body negative pressure Fulltext Access 10 Pages 2006
Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals Fulltext Access 10 Pages 2006
A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node—ablated, His bundle-paced dog Fulltext Access 10 Pages 2006
Current methods used to investigate G protein coupled receptor oligomerisation Fulltext Access 10 Pages 2006
Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs Fulltext Access 10 Pages 2006
Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways Fulltext Access 10 Pages 2006
Activation and apoptosis of mouse peritoneal macrophages by extracts of Larrea divaricata Cav. (jarilla) Fulltext Access 10 Pages 2006
Regioselective 2-hydroxylation of 17β-estradiol by rat cytochrome P4501B1 Fulltext Access 10 Pages 2006
Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary Fulltext Access 10 Pages 2006
15-Deoxy-Δ12,14-prostaglandin J2 induces renal epithelial cell death through NF-κB-dependent and MAPK-independent mechanism Fulltext Access 10 Pages 2006
Hepatic expression of heme oxygenase-1 and antioxidant response element-mediated genes following administration of ethinyl estradiol to rats Fulltext Access 10 Pages 2006
Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na+ and Ca2+ and PKA-independent increase of cytosolic Ca2+ associated with insulin secretion in hamster pancreatic β-cells Fulltext Access 10 Pages 2006
Involvement of guanylyl cyclase, protein kinase A and Na+K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor Fulltext Access 10 Pages 2006
Lymphatic endothelium: An important interactive surface for malignant cells Fulltext Access 10 Pages 2006
Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors Fulltext Access 10 Pages 2006
Differential effects of classical neuroleptics and a newer generation antipsychotics on the MK-801 induced behavioural primitivization in mouse Fulltext Access 10 Pages 2006
Are placebo-controlled trials still important for obsessive compulsive disorder? Fulltext Access 10 Pages 2006
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13) — A novel approach for the treatment of inflammatory bowel disease Fulltext Access 10 Pages 2006
Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice Fulltext Access 10 Pages 2006
Ketamine administration disturbs behavioural and distributed neural correlates of fear conditioning in the rat Fulltext Access 10 Pages 2006
Effects of maternal separation on neuropetide Y and calcitonin gene-related peptide in “depressed” Flinders Sensitive Line rats: A study of gene–environment interactions Fulltext Access 10 Pages 2006
No differences in calcium-binding protein immunoreactivity in the posterior cingulate and visual cortex: Schizophrenia and controls Fulltext Access 10 Pages 2006
Major depression and the synthetic enhancer substances, (−)-deprenyl and R-(−)-1-(benzofuran-2-yl)-2-propylaminopentane Fulltext Access 10 Pages 2006
Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: An association study Fulltext Access 10 Pages 2006
Aminoguanidine prevented impairment of blood antioxidant system in insulin-dependent diabetic rats Fulltext Access 10 Pages 2006
Mad2β, an alternative variant of Mad2 reducing mitotic arrest and apoptosis induced by adriamycin in gastric cancer cells Fulltext Access 10 Pages 2006
G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population Fulltext Access 10 Pages 2006
Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS) Fulltext Access 10 Pages 2006