Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: Synthesis, modelling and molecular pharmacology Fulltext Access 8 Pages 2005
Binding of β-d-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies Fulltext Access 8 Pages 2005
Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study Fulltext Access 8 Pages 2005
A radial distribution function approach to predict A2B agonist effect of adenosine analogues Fulltext Access 8 Pages 2005
The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase Fulltext Access 8 Pages 2005
A theoretical study of the different radical-scavenging activities of catechin, quercetin, and a rationally designed planar catechin Fulltext Access 8 Pages 2005
Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics Fulltext Access 8 Pages 2005
Biotin-labeled abscisic acid as a probe for investigating abscisic acid binding sites on plasma membranes of barley aleurone protoplasts Fulltext Access 8 Pages 2005
An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent Fulltext Access 8 Pages 2005
Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells Fulltext Access 8 Pages 2005
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates Fulltext Access 8 Pages 2005
Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy Fulltext Access 8 Pages 2005
4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity Fulltext Access 8 Pages 2005
QSAR study on thiazole and thiadiazole analogues as antagonists for the adenosine A1 and A3 receptors Fulltext Access 8 Pages 2005
Synthesis and evaluation of the permeability transition inhibitory characteristics of paramagnetic and diamagnetic amiodarone derivatives Fulltext Access 8 Pages 2005
Anti-inflammatory activity and QSAR studies of compounds isolated from Hyacinthaceae species and Tachiadenus longiflorus Griseb. (Gentianaceae) Fulltext Access 8 Pages 2005
Syntheses of quinolone hydrochloride enantiomers from synthons (R)- and (S)-2-methylpiperazine Fulltext Access 8 Pages 2005
Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal β-vinyl-substituted phosphotyrosyl mimetic Fulltext Access 8 Pages 2005
Stabilization of guanine quadruplex DNA by the binding of porphyrins with cationic side arms Fulltext Access 8 Pages 2005
Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-γ-activated murine macrophages Fulltext Access 8 Pages 2005
Copper-metalated peptide palindrome derived from prion octarepeat: synthesis, aggregation, and oxidative transformations Fulltext Access 8 Pages 2005
Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc Fulltext Access 8 Pages 2005
Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles Fulltext Access 8 Pages 2005
Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases Fulltext Access 8 Pages 2005
New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides Fulltext Access 8 Pages 2005
Synthesis and photodynamic activity of zinc(II) phthalocyanine derivatives bearing methoxy and trifluoromethylbenzyloxy substituents in homogeneous and biological media Fulltext Access 8 Pages 2005
Classical and three-dimensional QSAR for the inhibition of [3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells Fulltext Access 8 Pages 2005
Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies Fulltext Access 8 Pages 2005
NMR conformational analysis of p-tolyl furanopyrimidine 2â²-deoxyribonucleoside and crystal structure of its 3â²,5â²-di-O-acetyl derivative Fulltext Access 8 Pages 2005
Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site Fulltext Access 8 Pages 2005
Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates Fulltext Access 8 Pages 2005
Effects of 8-methyl-2â²-deoxyadenosine incorporation into quadruplex forming oligodeoxyribonucleotides Fulltext Access 8 Pages 2005
Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA Fulltext Access 8 Pages 2005
Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis Fulltext Access 8 Pages 2005
Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoromethoxy-d2-5-methoxybenzyl)acetamide: a deuterium-substituted radioligand for peripheral benzodiazepine receptor Fulltext Access 8 Pages 2005
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines Fulltext Access 8 Pages 2005
Synthesis and cellular studies of an octa-anionic 5,10,15,20-tetra[3,5-(nido-carboranylmethyl)phenyl]porphyrin (H2OCP) for application in BNCT Fulltext Access 8 Pages 2005
Thio-heterocylic naphthalimides with aminoalkyl side chains: novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins Fulltext Access 8 Pages 2005
Synthesis and biodistribution of [11C]R116301, a promising PET ligand for central NK1 receptors Fulltext Access 8 Pages 2005
Synthesis and anticancer activity of benzyloxybenzaldehyde derivatives against HL-60 cells Fulltext Access 8 Pages 2005
3D QSAR Markov model for drug-induced eosinophilia-theoretical prediction and preliminary experimental assay of the antimicrobial drug G1 Fulltext Access 8 Pages 2005
Synthesis and hybridization properties of the conjugates of oligonucleotides and stabilization agents. Part 3 Fulltext Access 8 Pages 2005
Quantitative structure and aldose reductase inhibitory activity relationship of 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3â²-pyrrolidine-1,2â²,3,5â²-tetrone derivatives Fulltext Access 8 Pages 2005
Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers Fulltext Access 8 Pages 2005
Structure-activity relationship study on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens Fulltext Access 8 Pages 2005
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate Fulltext Access 8 Pages 2005
Design and synthesis of (Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and (Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity Fulltext Access 8 Pages 2005
Preparation and structures of 6- and 7-coordinate salen-type zirconium complexes and their catalytic properties for oligomerization of ethylene Fulltext Access 8 Pages 2005
Synthesis and characterization of azole isoflavone inhibitors of aromatase Fulltext Access 8 Pages 2005
Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activity Fulltext Access 8 Pages 2005
Intrastrand base-stacking buttresses widening of major groove in interstrand cross-linked B-DNA Fulltext Access 8 Pages 2005
Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation Fulltext Access 8 Pages 2005
New ether diglycosides from Matayba guianensis with antiplasmodial activity Fulltext Access 8 Pages 2005
Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors Fulltext Access 8 Pages 2005
A new polyamine derivative, a structural analog of spermine, with in vivo activity as an inhibitor of ethanol appetite Fulltext Access 8 Pages 2005
A dihydrogen bond between a bridging hydride and the NH proton of a coordinated dimethylamine: solid state, solution and theoretical characterization Fulltext Access 8 Pages 2005
A new class of nitrogen based chiral ligands: 2H-1,3-benzoxazines. Ligand synthesis, X-ray structural studies and asymmetric catalysis Fulltext Access 8 Pages 2005
Synthesis and characterisation of new pyrazole–phosphinite ligands and their ruthenium(II) arene complexes Fulltext Access 8 Pages 2005
Tetra substituted thiophenes as anti-inflammatory agents: Exploitation of analogue-based drug design Fulltext Access 8 Pages 2005
Me3SiCC-CMeCH2 copper(I) β-diketonates: Synthesis, solid state structure, and low-temperature chemical vapour deposition Fulltext Access 8 Pages 2005
A series of new zirconium complexes bearing bis(phenoxyketimine) ligands: Synthesis, characterization and ethylene polymerization Fulltext Access 8 Pages 2005
Synthesis and crystal structures of cyclodiazastannoxides fused cyclopentadienyl M–Sn (M = Mo, W) bonded organometallic heterocycle Fulltext Access 8 Pages 2005
Metallocene-mediated synthesis of chain-end functionalized polypropylene and application in PP/clay nanocomposites Fulltext Access 8 Pages 2005
Another example of carborane based trianionic ligand: Syntheses and catalytic activities of cyclohexylamino tailed ortho-carboranyl zirconium and titanium dicarbollides Fulltext Access 8 Pages 2005
Polymerization of MMA by oscillating zirconocene catalysts, diastereomeric zirconocene mixtures, and diastereospecific metallocene pairs Fulltext Access 8 Pages 2005
Two-carbon homologation of ketones via sily ketene acetals: Synthesis of α,β-unsaturated acids and α-trimethylsilyl δ-ketoacids Fulltext Access 8 Pages 2005
Chiral diethylzinc complexes with diamine ligands: synthesis, crystal structure and enantioselective solvent-free alkylation Fulltext Access 8 Pages 2005
Reversible aryl C–H bond activation in the reaction between HRu3(CO)9,10(μ-PPh2) and the diphosphine ligand 4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione (bpcd): X-ray diffraction structures of H2Ru3(CO)7(bpcd)[μ,σ-PPh(C6H4)] and Ru3(CO)6(μ-CO)(μ-PPh Fulltext Access 8 Pages 2005
Theoretical simulation of the electronic circular dichroism spectrum of calicheamicin Fulltext Access 8 Pages 2005
Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity Fulltext Access 8 Pages 2005
Comparison of positively charged DNG with DNA duplexes: a computational approach Fulltext Access 8 Pages 2005
Synthesis and preliminary biological evaluation of O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy Fulltext Access 8 Pages 2005
Synthesis and pharmacological activities of some mononuclear Ru(II) complexes Fulltext Access 8 Pages 2005
Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: Further evidence for the existence of an abnormal pathway for heme biosynthesis Fulltext Access 8 Pages 2005
Synthesis and biological evaluation of new 4β-anilino- and 4β-imido-substituted podophyllotoxin congeners Fulltext Access 8 Pages 2005
‘O-Acyl isopeptide method’ for the efficient preparation of amyloid β peptide 1–42 mutants Fulltext Access 8 Pages 2005
Identification and characterization of small molecule modulators of KChIP/Kv4 function Fulltext Access 8 Pages 2005
Organic synthesis in pursuit of immunology: Large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine Fulltext Access 8 Pages 2005
The solution structure of a lasalocid A metal complex in lipophilic solvents Fulltext Access 8 Pages 2005
Synthesis and characterisation of the platinum complexes [PtCl(CClPAr)(PPh3)2] and [PtCl(CClPAr′)(PPh3)2] as potential intermediates in the preparation of phosphaalkynes Fulltext Access 8 Pages 2005
New reagents for phosphatidylserine recognition and detection of apoptosis Fulltext Access 8 Pages 2005
Synthesis of chromenochalcones and evaluation of their in vitro antileishmanial activity Fulltext Access 8 Pages 2005
Synthesis of some monocyclic analogues of mycophenolic acid via the Johnson ortho ester Claisen rearrangement Fulltext Access 8 Pages 2005
Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives Fulltext Access 8 Pages 2005
Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile Fulltext Access 8 Pages 2005
Oxidation of liposomal membrane suppressed by flavonoids: Quantitative structure-activity relationship Fulltext Access 8 Pages 2005
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis Fulltext Access 8 Pages 2005
Design and synthesis of N-benzylpiperidine–purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase Fulltext Access 8 Pages 2005