Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2019167 | Progress in Lipid Research | 2012 | 11 Pages |
Abstract
Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Through interactions with signaling molecules, both PLD and PA can mediate a variety of cellular functions, such as, growth/proliferation, vesicle trafficking, cytoskeleton modulation, development, and morphogenesis. Therefore, systemic approaches for investigating PLD networks including interrelationship between PLD and PA and theirs binding partners, such as proteins and lipids, can enhance fundamental knowledge of roles of PLD and PA in diverse biological processes. In this review, we summarize previously reported protein-protein and protein-lipid interactions of PLD and PA and their binding partners. In addition, we describe the functional roles played by PLD and PA in these interactions, and provide PLD network that summarizes these interactions. The PLD network suggests that PLD and PA could act as a decision maker and/or as a coordinator of signal dynamics. This viewpoint provides a turning point for understanding the roles of PLD-PA as a dynamic signaling hub.
Keywords
RTKPDGFAMPKPKNARFmTORC1LPAPI(3,4)P2CRMP-2PKCProtein kinase NGEFcdk5GPCRBinding partnersPDECollapsin response mediator protein-2JAK3mTORCEMGDIJanus kinase 3EGFPLDEGFRAMP-activated protein kinasePMAmTOR complex 1PI(3,4,5)P3PI(4,5)P2phosphatidic acidlysophosphatidic acidPhorbol esterRTK, Receptor tyrosine kinasesignaling dynamicscyclin-dependent kinase 5Interaction networkGAPepidermal growth factorADP-ribosylation factorguanine nucleotide exchange factorplatelet-derived growth factorphosphatidylinositol 3,4-bisphosphatephosphatidylinositol 3,4,5-trisphosphatePhosphatidylinositol 4-phosphate 5-kinasephosphatidylinositol 4,5-bisphosphatePhosphatidylinositol 5-phosphatePhosphodiesterasePhosphoinositidesPhospholipase Dguanine nucleotide dissociation inhibitorNetwork motifmammalian target of rapamycinphox homologyPleckstrin HomologyGTPase-activating proteinProtein kinase CEGF receptorG protein-coupled receptor
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Authors
Jin-Hyeok Jang, Chang Sup Lee, Daehee Hwang, Sung Ho Ryu,