| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2098554 | Trends in Food Science & Technology | 2015 | 11 Pages |
•Beta-glucan exhibit a broad spectrum of biological activities.•Latest research progress on anti-inflammatory effects of glucans was reported.•In vitro anti-inflammation effects of fungal β-glucans were summarized.•Animal studies on anti-inflammation effects of fungal β-glucans were reviewed.•Human studies on anti-inflammation effects of fungal β-glucans were presented.
β-Glucans from fungi exhibit a broad spectrum of biological activities including anti-tumor, immune-modulating and anti-inflammatory properties. The anti-inflammatory effect is mediated through the regulation of various inflammatory cytokines, such as nitric oxide (NO), interleukins (ILs), tumor necrosis factor alpha (TNF)-α, interferon gamma (INF)-γ as well as non-cytokine mediator, prostaglandin E2 (PGE2). Up to now, the anti-inflammatory activity of β-glucans has received little attention. It is worthwhile to investigate the anti-inflammatory properties of fungal β-glucans in a separate review, discussing in vitro studies, animal studies and human studies on anti-inflammation effects of fungal β-glucans, as well as the structure-anti-inflammatory activity relationships.
