| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2435197 | International Dairy Journal | 2009 | 6 Pages |
Abstract
The effects of a Lactobacillus casei 393 fermented milk product (FMP) on bone metabolism were examined. FMP (>0.1 mg mL−1) supplementation significantly increased osteoblastic MC3T3-E1 cells proliferation whereas skim milk powder supplementation did not show any positive effect up to 1 mg mL−1. The FMP (1%) supplemented ovariectomised rats had increased bone weight, bone mineral density, and bone breaking force compared with control ovariectomised rat. In addition, the activity of tartrate resistant acid phosphatase, a biomarker of osteoclasts, was significantly reduced in the FMP group. Based on the results, the L. casei 393 FMP had a preventative effect on bone loss in ovariectomised rats.
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Authors
Jong Gun Kim, Eungsuk Lee, Sae Hun Kim, Kwang Youn Whang, Sejong Oh, Jee-Young Imm,