Salivary α-amylase: A measure associated with satiety and subsequent food intake in humans

Food intake regulation in humans involves various central and peripheral mechanisms. In this study salivary α-amylase was examined for functioning as a measure of satiety and food intake. In a 1.25-h session, 32 fasted subjects were given a preload of starch-based custard (849 kJ) followed by ad libitum intake of this custard. Before and after preload intake and after ad libitum consumption, both satiety ratings and α-amylase were analysed. Perceived satiety and α-amylase were increased after preload and ad libitum consumption. Across subjects, the individual amount of ad libitum intake was negatively correlated to α-amylase levels before this intake, whereas it was positively associated with α-amylase activity after ad libitum consumption. In conclusion, salivary α-amylase systematically increases upon food consumption and satiation, and serves therefore as a potential measure of satiety and subsequent food intake.