Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2507425 | Journal of Food and Drug Analysis | 2014 | 7 Pages |
Abstract
The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.
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Authors
Subham Banerjee, Pronobesh Chattopadhyay, Animesh Ghosh, Shiv Sankar Bhattacharya, Amit Kundu, Vijay Veer,