β-Cryptoxanthin rich paprika extract prevents ovariectomy induced bone loss in Wistar rats

•β-Cryptoxanthin rich paprika extract significantly increased the bone density in experimental animals.•β-Cryptoxanthin rich paprika extract increased bone mechanical strength and protection from bone fragility.•β-Cryptoxanthin rich paprika extract reduced urinary calcium excretion in ovariectomized rats.

Recent studies show that high intake of carotenoids is helpful in preventing bone loss in post-menopausal women. Carotenoids like β-cryptoxanthin increases calcium and phosphorus deposition in cultured osteoblasts. β-Cryptoxanthin is also reported to have anabolic property in cultured osteoblast cells. It can also inhibit bone resorption process. Paprika and its dietary products are rich in carotenoids like β-cryptoxanthin. Carotenoids from the paprika oleoresin are also reported to have very good bioavailability in humans. The present study was carried out to investigate the effect of β-cryptoxanthin rich paprika extract on animal model of ovariectomy induced bone loss. Treatment with the test drug was given for 6 weeks. The β-cryptoxanthin rich paprika extract significantly reduced urinary excretion of pyridinium crosslinks, indicating its probable anti-resorptive property. The mechanical strength and density of cancellous bones are significantly improved. Thus the paprika extract may have potential role as a sustainable nutritional approach to improving bone health in post-menopausal condition.

Graphical AbstractFigure optionsDownload full-size imageDownload as PowerPoint slide