| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2585094 | Food and Chemical Toxicology | 2013 | 7 Pages |
•Artocarpin attenuates UVB-induced sunburn effect.•Artocarpin is an antioxidant to prevent UVB-induced skin oxidative stress.•Artocarpin is an anti-inflammtory agent to prevent UVB-induced skin inflammation.•Artocarpin played as a photoprotective agent to prevent skin damage.
Artocarpin, a prenylated flavonoid isolated from an agricultural plant Artocarpus communis, has been documented to possess anti-inflammation and anticancer activities. As oxidative stress and inflammation promote the development of ultraviolet B (UVB) irradiation-induced photodamage, the aim of the present study was to evaluate the photoprotective effect of artocarpin on UVB-induced skin damage in hairless mice. Artocarpin at a topical dose of 0.05% and 0.1% showed a significant photoprotective effect by decreasing histopathological changes, such as desquamation, epidermal thicken and sunburn cell formation, but 0.1% of artocarpin administration did not show better effect. Regarding the antioxidant activities, artocarpin exhibited a significant effect (P < 0.05) by decreasing levels of reactive species oxygen and lipid peroxidation. In addition, artocarpin can significantdecrease the level of tumor necrosis factor-α and interleukin-1β for downregulating the inflammation protein, including the synthesis of cytosolic phospholipase A2 and cyclooxygenase-2 (P < 0.05). In conclusion, these data suggest that artocarpin can prevent skin damage from UVB irradiation-induced photodamage in hairless mice and this is likely mediated through its antioxidant and anti-inflammation mechanisms. Therefore, we suggested that artocarpin could be a useful photoprotective agent in medicine and/or cosmetics.
Graphical abstractArtocarpin prevents UVB-induced skin damage.Figure optionsDownload full-size imageDownload as PowerPoint slide
