Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2585096 | Food and Chemical Toxicology | 2013 | 6 Pages |
•Toddalia asiatica is used for treating various diseases.•In vitro antioxidant activity of T. asiatica leaves.•Hypolipidemic activity of T. asiatica on triton and high fat diet induced models.•T. asiatica showed good hypolipidemic activity.
The present study was undertaken to evaluate the in vitro antioxidant and antihyperlipidemic activity of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet-induced hyperlipidemic rats. In in vitro studies T. asiatica leaves ethyl acetate extract showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC50 605.34 ± 2.62 μg/ml), hydroxyl (IC50 694.37 ± 2.12 μg/ml) and nitric oxide (IC50 897.83 ± 1.48 μg/ml) radicals, as well as high reducing power. In Triton WR-1339 induced hyperlipidemic rats, oral treatment with T. asiatica leaves ethyl acetate extract produced a significant (P ⩽ 0.005) decrease in the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and significant increase in high-density lipoprotein cholesterol (HDL-C) in comparison with hexane and methanol extracts. In high fat diet-fed hyperlipidemic rats, the ethyl acetate extract (200 and 400 mg/kg) significantly altered the plasma and liver lipids levels to near normal.