| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2585264 | Food and Chemical Toxicology | 2013 | 5 Pages |
Abstract
⺠This is a first report concerning cytotoxicity, CYP450 inhibition and antioxidant activity of Mutellina purpurea extracts. ⺠The aqueous extract is characterised as having considerably minor influence on CYP4A4 and CYP2D6 isoenzymes. ⺠The higher cytotoxicity is observed for methanolic extract, on both BHK-21 and HeLa cell lines. ⺠The both M. purpurea extracts have quite similar antioxidant activity in ABTS assay. ⺠Tested extracts are likely to inhibit drug metabolizing enzymes, but less likely to produce significant drug interactions.
Keywords
DMFCYP2D6CYP3A4ABTSFBSSDSPBS(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)DMSOMTTeagle’s minimal essential mediumdimethylsulphoxidedimethylformamidesodium dodecyl sulphatefetal bovine serumCytotoxicityPhosphate buffered salineAntioxidant activityMEM
Related Topics
Life Sciences
Agricultural and Biological Sciences
Food Science
Authors
Elwira Sieniawska, Tomasz Baj, JarosÅaw Dudka, Renata Gieroba, Lukasz Swiatek, Barbara Rajtar, Kazimierz Glowniak, MaÅgorzata Polz-Dacewicz,