| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2585631 | Food and Chemical Toxicology | 2010 | 8 Pages |
Abstract
Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model. Dose–response modelling results in a BMDL10 of 250 ng/kg-bw/d. Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600.
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Authors
Diane Benford, Jean-Charles Leblanc, R. Woodrow Setzer,