Article ID Journal Published Year Pages File Type
2585633 Food and Chemical Toxicology 2010 8 Pages PDF
Abstract

The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 106 to 0.4 x 106 depending on the assumptions used in the exposure estimation.

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Life Sciences Agricultural and Biological Sciences Food Science
Preview
Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: Example: Benzene, CAS: 71–43-2
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