Evaluation of genotoxic effects of semicarbazide on cultured human lymphocytes and rat bone marrow

Comparing MN and SCE frequencies on control and examined concentrations (0.5, 2.5, 5, 10 and 20 μg ml−1) did not reveal statistically significant differences except, marginally, the highest concentration (20 μg ml−1) in SCE analysis. On the other hand, oral administration of 50, 100 and 150 mg kg−1 b.w. of SEM showed a statistically significant effect in MN frequencies on Wistar rats' bone marrow PCEs, with no dose-response pattern.