Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2586129 | Food and Chemical Toxicology | 2009 | 5 Pages |
Abstract
A subchronic oral toxicity study was conducted to evaluate the safety of l-serine in Sprague–Dawley rats. The test article was administered once daily by gavage in male and female rats at dose levels of 0, 500, 1500, and 3000 mg/kg body weight/day for 13 weeks. Daily clinical signs, body weight, and food consumption were not affected by ingestion of the test article. There were no treatment-related adverse effects on urinalysis, hematology, serum biochemistry, organ weights, gross and histopathological examination. It was concluded that the no-observed-effect level (NOEL) for l-serine was 3000 mg/kg bw/day for both genders.
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Authors
I. Kaneko, L. Han, T. Liu, J. Li, Y. Zhao, C. Li, Y. Yi, A. Liang, K. Hayamizu,