Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2586284 | Food and Chemical Toxicology | 2009 | 4 Pages |
Abstract
The anti-diabetic efficacy of Hydrangea dulcis folium (HDF) was studied in db/db mice and their littermates (db/-). Supplementation of HDF (1% and 3%) decreased glucose level significantly by 2- and 4-fold and increased significantly insulin level by 3- and 4.5-fold compared to db/db mice (P < 0.05). Administration of HDF (1% and 3%) ameliorates hyperglycemia and improves glucose homeostasis in db/db mice in a dose-dependent manner by preventing loss of β-cell mass resulting in increase of insulin secretion. In addition, 3% HDF treatment significantly reduced the food intake, weight gain, and blood lipids in db/db mice.
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Authors
Mi-Ja Kim, Kang-Hyun Leem, Hye Kyung Kim,