Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2586664 | Food and Chemical Toxicology | 2007 | 5 Pages |
Abstract
Jamaica quassia extract (JQE), a natural bittering agent, was investigated for hepatocarcinogenesis-promoting potential using a medium-term liver bioassay system. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (200Â mg/kg body weight) and then starting 2 weeks later, received JQE in the diet at concentrations of 500, 5000 or 30,000Â ppm for 6 weeks. Animals for tumor promotion (+) and (â) controls were fed 500Â ppm sodium phenobarbital (PB) and basal diet, respectively during the promotion phase in this model. All animals were subjected to two-thirds partial hepatectomy at week 3 and killed at week 8. As with the PB-promoted case, both numbers and areas of glutathione S-transferase placental form-positive liver cell foci were significantly increased by JQE at 30,000Â ppm, with non-significant increases evident at 5000Â ppm. The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis.
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Authors
Gye-Hyeong Woo, Makoto Shibutani, Kaoru Inoue, Hitoshi Fujimoto, Miwa Takahashi, Kyoung-Youl Lee, Masao Hirose,