Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2587051 | Food and Chemical Toxicology | 2006 | 12 Pages |
Abstract
Pregnant Sprague-Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000Â ppm) and methylethylketone (MEK; 0, 1000, or 3000Â ppm), alone and in combination, by inhalation, for 6Â h/day, during days 6-20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000Â ppm EB and 3000Â ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000Â ppm EB or 3000Â ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity.
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Authors
A.M. Saillenfait, F. Gallissot, J.P. Sabaté, N. Bourges-Abella, R. Cadot, G. Morel, A.M. Lambert,