| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2587871 | Food and Chemical Toxicology | 2006 | 7 Pages |
Red palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF).Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO2 asphyxiation. Numbers of ACF (mean ± SE) in the proximal and distal colon were: 39.9 ± 0.9, 53.8 ± 2.8, 26.0 ± 3.0, 27.5 ± 1.5 and 118.2 ± 1.7, 125.6 ± 3.2, 41 ± 7, 52.3 ± 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively.The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.
