The configurable-biomolecular nano pattern controlled by surface potential

Biomolecular patterning on surfaces plays a critical role in the field of biochip developments. Therefore, we designed and fabricated a device to realize the programmable biomolecular patterning technique driven by electrical surface potentials. In this work, the electrical surface potential was used to control the hydrophobicity of surfaces. Utilizing hydrophobicity interactions, the adhesion affinity between biomolecules and chip surfaces can be modulated by the applied electrical field. By activating the electrical potential of specific electrodes, biomolecules can attach to specific regions as designed or programmed. Based on this technique, in addition, we demonstrated the 250 nm width bovine serum albumin (BSA) pattern with a 5-min operation. This work shows the potential for various biomolecular applications and research fields.