Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review

•Cordyceps sinensis and cordycepin stimulate mouse Leydig cell steroidogenesis.•Cordyceps sinensis and cordycepin activate PKA pathway in Leydig cells.•Cordyceps sinensis and cordycepin could enhance male reproduction.

Cordyceps sinensis has various biological and pharmacological functions, and it has been claimed as a tonic supplement for sexual and reproductive dysfunctions for a long time in oriental society. In this article, the in vitro and in vivo effects of C. sinensis and cordycepin on mouse Leydig cell steroidogenesis are briefly described, the stimulatory mechanisms are summarized, and the recent findings related to the alternative substances regulating male reproductive functions are also discussed.

Graphical abstractCordyceps sinensis and cordycepin can significantly stimulate in vitro and in vivo steroidogenesis in mouse Leydig cells through the activation, at least, of the protein kinase A pathway, highly suggesting functional enhancements in male reproduction.Download high-res image (93KB)Download full-size image