RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0

•l-Linalool safety assessment based on RIFM's criteria.•Safety assessment based on 7 Human health endpoints plus environmental.•Repeated dose toxicity was determined to have the most conservative NO[A]EL.•An acceptable MOE was obtained.

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.