Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5849339 | Food and Chemical Toxicology | 2016 | 7 Pages |
Abstract
This study was conducted to investigate the toxic effects of deoxynivalenol (DON) and the ameliorating efficacy of Devosia sp. ANSB714 for the negative effects of DON on mice. In the experiment, 80 mice were randomly divided into 4 treatments: non-toxin control, toxin, non-toxin control + ANSB714 and toxin + ANSB714. During 28 days, the mice in treatment with 4.70 mg/kg DON only had significantly lower average daily gain as compared those with non-toxin control treatment (P < 0.05). Serum blood urea nitrogen, tumour necrosis factor-α and the residues of DON in kidneys in mice received the toxin diet were obviously higher than those with non-toxin control (P < 0.05). There were no significant differences (P > 0.05) between ANSB714 treatments and non-ANSB714 treatments on above parameters of mice. Adding ANSB714 to toxic diets could normalize deviant physiological effects of DON on mice.
Keywords
ALTF/GIgMBiological transformationADGADFIIL-2IL-1βFHBDeoxynivalenolALBIgGCREIL-6PBSaspartate amino transferaseASTAlanine aminotransferaseAlbuminALPAlkaline phosphataseIgAinterleukin-6Interleukin-1βInterleukin-2ResiduesELISAEnzyme-linked immunosorbent assaynot detectedtumour necrosis factor-αstandard errorBUNDONFusarium head blightGrowth performanceTNF-αPhosphate buffered salineaverage daily gainAverage daily feed intakeblood urea nitrogencreatininehigh performance liquid chromatographyHPLCtotal protein
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Authors
Lihong Zhao, Xiaoying Li, Cheng Ji, Xiaoping Rong, Shujing Liu, Jianyun Zhang, Qiugang Ma,