Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5849615 | Food and Chemical Toxicology | 2015 | 7 Pages |
Abstract
The caffeine dose of 200Â mg per day is declared as safe for pregnant women with respect to the foetus by EFSA based on results on reduced birth weight in epidemiological studies. We modelled AUC and peak concentration for different caffeine doses to investigate the relationship between internal caffeine exposure and risk measures of reduced birth weight from epidemiological studies. The graphical analysis revealed that the reduction in birth weight was related to AUC and peak concentration up to a dose of 250Â mg caffeine.
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Authors
F. Partosch, H. Mielke, R. Stahlmann, U. Gundert-Remy,