Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5850027 | Food and Chemical Toxicology | 2014 | 6 Pages |
Abstract
One of the most abundant oligosaccharides found in human milk is 2â²-fucosyllactose, a trisaccharide composed of fucose and lactose, and multiple studies have demonstrated a health benefit to this compound. Recent advances have allowed for the large-scale production of oligosaccharides via fermentation, including 2â²-fucosyllactose. A neonatal piglet model was used to evaluate the tolerability of 2â²-fucosyllactose, produced through this process, in order to demonstrate the suitability of this compound for human infants under 12 weeks of age. Crossbred farm piglets, at lactation day 2, were assigned to one of four treatment groups receiving a liquid diet containing 0, 200, 500 or 2000âmg/L of 2â²-fucosyllactose. The calculated consumption of 2â²-fucosyllactose corresponded to dose levels of 29.37, 72.22 and 291.74âmg/kg/day, respectively, in males and 29.30, 74.31, and 298.99âmg/kg/day, respectively in females. Piglets were administered diet for 3 weeks; and there were no test article-related effects on growth and development (clinical observations, body weight and food consumption), clinical pathology parameters (hematology, clinical chemistry, coagulation and urinalysis), or any histopathologic changes. Therefore, dietary exposure to 2â²-fucosyllactose at concentrations up to 2000âmg/L was well tolerated by neonatal farm piglets and did not result in adverse health effects or impact piglet growth.
Keywords
FDAGGTCHOLCREGLPsorbitol dehydrogenaseOECDLEUALT2′-FucosyllactoseHMOALBASTAspartate aminotransferaseAlanine aminotransferaseAlbuminAlkaline phosphataseEosinophilsEryErythrocyteshuman milk oligosaccharidebasophilsBASObilPigletBilirubinTriglyceridesInfant nutritionGood Laboratory PracticeReticulocytesFood and Drug AdministrationOrganisation for Economic Co-operation and DevelopmentSodiumretiPhosphorusLymphocytesLeukocytesmonoMonocytesNeutNeutrophilsurea nitrogenHEMAhematocritHemoglobinPotassiumcreatinetotal proteinChloridecholesterolCalciumgamma glutamyltransferaseGlucGlucose
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Authors
Paul R. Hanlon, Bjorn A. Thorsrud,