Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5850616 | Food and Chemical Toxicology | 2014 | 6 Pages |
Abstract
Despite widespread use of Eriosema laurentii De Wild (Leguminosae) in West and Central Africa as herbal medicine and food additive the toxicity of this plant is unknown. Therefore, we performed the safety evaluation of a methanol extract (AEL). In acute toxicity, single oral administration of 2000Â mg/kg AEL caused neither toxicological symptoms nor mortality and the LD50 was estimated >5000Â mg/kg. In the subchronic oral toxicity, AEL induced no phenotypical signs of toxicity during and after treatment. Only a delayed decrease of relative spleen weight in males at the highest dose of 400Â mg/kg occurred. High density lipoprotein (HDL) increased significantly in females at 200 and 400Â mg/kg. Non-persistent increases in alanine aminotransferase activity within normal ranges were noted at 200Â mg/kg in males and at all doses in females. In males, AEL induced a decrease of white blood cell count at 400Â mg/kg, whereas lymphocytes increased at 200 and 400Â mg/kg and granulocytes at 400Â mg/kg. In females, no differences in haematological parameters occurred. Neither differences in bilirubin, creatinine and total protein levels were observed nor histological alterations in organs. The results indicate a broad safety margin for AEL.
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Authors
Sylvin Benjamin Ateba, Rudy Valdès Simo, Jean Claude Mbanya, Liselotte Krenn, Dieudonné Njamen,